THE CORRELATION BETWEEN SERUM TEF3 AND SERUM SFRP5, KLOTHO, GALECTIN-3, AND NESFATIN-1 IN PATIENTS WITH DIABETIC NEPHROPATHY

Haiyan Li¹, Xiao Ding², Yanping Yang^3*

¹Department of Geriatrics, No.215 Hospital of Shanxi nuclear industry, Xianyang city 712000, China - ²The first outpatients department of the General Hospital of Western Theater Command PLA, Chengdu 610015,China - ³Department of Nephrology, No.215 Hospital of Shanxi nuclear industrymmy, Xianyang city 712000, China

Objective: To explore the correlation between serum trefoil factor 3 (TEF3) and serum-secreted frizzled-related protein 5 (SFRP5), Klotho, galectin-3, and new satiety molecular protein 1 (nesfatin-1) in patients with diabetic nephropathy. 

Methods: First, 56 adult patients hospitalized with diabetic nephropathy in the Department of Endocrinology of the Third Central Hospital of Tianjin between April 2017 and June 2019 were recruited as the diabetic nephropathy group. Meanwhile, 56 adult patients undergoing physical examination in the hospital during the same period were recruited as the control group. The fasting venous blood of each group was centrifuged and the supernatant was collected for testing. The serum levels of TEF3, SFRP5, Klotho, galectin-3, nesfatin-1, interleukin-6 (IL-6), IL-18, and high-sensitivity C-reactive protein (hs-CRP) were compared and their correlations were analyzed. 

Results: The TEF3, IL-18, IL-6, and hs-CRP levels of the diabetic nephropathy group were significantly higher than those of the control group, whereas the SFRP5, Klotho, serum galectin-3, and nesfatin-1 levels were significantly lower (P<.05). We analyzed the correlation, taking TEF3 as the dependent variable and SFRP5, Klotho, galectin-3, nesfatin-1, IL-18, IL-6, hs-CRP as the independent variables. We found that TEF3 was negatively correlated with SFRP5, Klotho, galectin-3, and nesfatin-1 (P<.05) and positively correlated with IL-18, IL-6, and hs-CRP (P<.05). 

Conclusion: The serum of patients with diabetic nephropathy had lower levels of TEF3, SFRP5, Klotho, galectin-3, and nesfatin-1 and higher levels of related inflammatory factors. The expression level of TEF3 was negatively correlated with SFRP5, Klotho, galectin-3, and nesfatin-1, and positively correlated with inflammatory factors. This indicates that TEF3 can be used as an important indicator in the clinical monitoring of patients with diabetic nephropathy.