STUDY ON THE RISK OF DEATH OF COAGULATION INDEX IN PATIENTS WITH COVID-19

Yongjuan Zhao^1,#, Yueying Wang^2,#, Zhijun Li², Xinwei Li², Mengdi Jin², Yang He², Yang Liu², Ningning Jia², Xingyao Cui², Yane Liu², Guoyan Hu², Lin Yang³, Bo Yang⁴, Nan Jiang^3,*, Qiong Yu^2,*

¹Department of Respiratory, China-Japan Union Hospital of Jilin University, Changchun 130021, China - ²Department of Epidemiology and Biostatistics, School of public health, Jilin University, Changchun 130021, China - ³Department of Trauma Center, China-Japan Union Hospital of Jilin University, Changchun 130021, China - ⁴Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China 

Objective: The aim of this study was to elucidate the association of COVID-19 prognosis with the indexes of inflammation and coagulation. 

Methods: The clinical data of 103 cases of COVID-19 were retrospectively analyzed. COX regression models and 95% confidence intervals (CIs) were applied to estimate the COVID-19 prognosis.

Results: The results showed that C-reactive protein (HR=1.007, p<0.001), procalcitonin (HR=1.013, p=0.006), prothrombin time (HR=1.190, p<0.001), Fibrinogen (HR=0.784, p=0.002) and D-dimer (HR=1.078, p<0.001) is associated with an increased risk of COVID-19 death. Among the inflammation indicators, the maximum area under the ROC curve of NLR is 0.87. In the coagulation index, the maximum area under the ROC curve of PT is 0.84. For the combined indicators of inflammation and coagulation, the area under the ROC curve is 0.89.

Conclusions: In conclusion, we found that the length of PT at admission and the level of fibrinogen and D-dimer were related to the risk of COVID-19 death. It may be considered to jointly predict the risk of death of COVID-19 with inflammation and coagulation indicators.