RISK FACTORS FOR REDUCED QUALITY OF LIFEIN CKD PATIENTS OVER 65 YEARS OLD

Min Wang¹, Li Li², Kaili Wang^3,*

¹Emergency Department, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570102, PR China - ²Blood Purification Center, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570102, PR China - ³Department of Medicine, Guangxi University of Science and Technology, Liuzhou, Guangxi Zhuang Autonomous Region 545005, PR China

Objective: To investigate the risk factors for reduced quality of life inchronic kidney disease(CKD) patients over 65 years old. 

Methods: 378 CKD patients over 65 years old treated in our hospitalfrom January 2016 to January 2021 were included in this study. The baseline clinical data and Brief Comprehensive Geriatric As-sessment (CGA) score were analyzed, and the correlation between Basic Activities of Daily Living (BADL) score and Instrumental Activities of Daily Living (IADL) score and relevant clinical indica-torswas evaluated. A multiple linear regression model was employed to evaluate the independent risk factors of the decline in BADL score and IADL score. 

Results: The correlation analysis showed that the levels of eGFR, UA, LDL-C, HDL-C, serum K+ and serum Cl- were positively correlated with BADL score (P<0.05). BNP was negatively correlated with BADL score (P<0.05). The levels of eGFR, UA, HDL-C, LDL-C, serum K+ and serum Cl- were positively correlated with IADL score (P<0.05). Age and BNP were negatively correlated with IADL score (P<0.05).The multivariate analysis showed that the decline in eGFR level was an independent risk factor for the decrease of BADL score (P<0.05). The increase of age and decline in eGFR level were independent risk factors for the decline in IADL score in patients (P<0.05). 

Conclusion: The reduced quality of life in CKD patients over 65 years old is closely related to the increase of age andeGFR level.