EFFECTS OF DIFFERENT DOSES OF DEXMEDETOMIDINE IN PATIENTS WITH COLORECTAL CANCER

Yuhua Kong^{1, #}, Zhuoya Bai^{1, #}, Lin Chen², Yongling Yao^{3, *}

¹Department of Anesthesiology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, 322200, China - ²Department of Urinary surgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, 322200, China - ³Department ofPain, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, 322200, China 

Objective: To explore the effects of different doses of dexmedetomidine (DEX) on emergence agitation after anesthesia and postoperative pain in colorectal cancer (CRC) patients after radical resection.

Methods: A total of 180 CRC patients undergoing radical resection treated in our hospital from January 2019 to January 2020 were selected as the research objects and divided into group A (n=60), group B (n=60) and group C (n=60)based on the administration method. Groups A and B were given 0.4 μg•kg-1 and 0.8 μg•kg-1DEX respectively with pump injection during anesthesia induction and group C was injected with the same amount of normal saline to compare their agitation scores, sedation scores, inflammatory factor levels, recovery time, postoperative pain scores and incidences of adverse reactions.

Results: Compared with group C, groups A and B achieved significantly lower agitation scores (P<0.001) and significantly higher sedation scores (P<0.001), and the sedation score of group A was significantly lower than that of group B (P<0.001); group A and group B showed significantly higherintraoperative and wake-up levels of interleukin 10 (IL-10) (P<0.001) and significantly lower levels of tumor necrosis factor (TNF-α) and C-reactive protein (CRP) (P<0.001) than Group C; between group A and group B, the level of IL-10 was significantly lower (P<0.001) and the levels of TNF-α and CRP were significantly higher in group A (P<0.001); the recovery time of group A was significantly shorter than that of groups B and C (P<0.001);groups A and B achieved significantly lower postoperative pain scores than group C (P<0.05); and groups A and C achieved significantly lower incidences of adverse reactions compared with group B (P<0.05).

Conclusion: For patients undergoing radical resection of colorectal cancer, 0.4 μg•kg-1 DEX can ease the emergence agitation after anesthesia, improve the inflammatory factor level, alleviatethe postoperative pain, and lower the possibility of adverse reactions, which should be promoted and applied.