CORRELATION OF SERUM HOMOCYSTEINE, CYSTATIN C AND URIC ACID AND CEREBRAL CIRCULATION DYNAMICS IN PATIENTS WITH H-TYPE HYPERTENSION

Shaoping Shen^{1, *}, Yilin Mao², Huimin Shen¹, Qingcheng Wang¹, Xiangming Tian¹

¹Department of Cardiology, Hangzhou Yuhang Hospital of Traditional Chinese Medicine, Hangzhou 311106, PR China - ²Department of Cardiology, Hunan Provincial Hospital of Traditional Chinese Medicine, Changsha 410000, PR China

Objective: To investigate the correlation between serum homocysteine, cystatin C, uric acid, and cerebral circulation dynamics in patients with H-type hypertension. 

Methods: Forty patients with H-type hypertension who were treated in the Department of Cardiology of our hospital from May 2019 to April 2020 were randomly selected as the study group. Forty healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group. The basic clinical data of all research subjects were compared. The serum levels of Hcy, Cys-C, and uric acid (UA) in the study group and the control group were determined. Changes in cerebral circulation dynamics indexes of the two groups were detected. Pearson’s correlation test was used to analyze the correlation between serum Hcy, Cys-C, UA, and cerebral circulation dynamics in patients with H-type hypertension. 

Results: No statistically significant difference was observed between the two groups in basic data such as gender, age, body mass index, fasting blood glucose, and blood lipids (P>0.05). Compared with the control group, the blood pressure of the patients in the study group increased significantly (P<0.01). Compared with the control group, the serum levels of Hcy, Cys-C, UA, dynamic resistance (DR), Zc, peripheral resistance (PR), critical pressure (CP), and Wv in the study group were significantly increased, and the levels of Vmean and Qmean were significantly decreased (P<0.05 or P<0.01). Pearson correlation test analysis showed that serum Hcy, Cys-C, UA levels were significantly positively correlated with DR, Zc, PR, CP, and Wv, and significantly negatively correlated with Vmean and Qmean (P<0.05). 

Conclusion: Serum Hcy, Cys-C, and UA levels of H-type hypertension are significantly higher than those of healthy subjects, and there are obvious abnormal cerebral circulation dynamics. Moreover, serum Hcy, Cys-C, and UA levels are significantly related to cerebral circulation dynamics.