CORRELATION BETWEEN SERUM IRREGULAR CHEMOKINE FRACTALKINE AND HS-CRP, ET-1, ADMA LEVELS IN PATIENTS WITH ESSENTIAL HYPERTENSION

Bin Sun¹, Jian Liang^{2, *}

¹No.2 Department of Cardiology, Jining First People’s Hospital, Jining 272000, PR China - ²Department of Cardiovascular Medicine, Shizhu County People's Hospital, Chongqing 409199, PR China

Objective: To study the correlation between the serum irregular chemokine fractalkine (FKN) and hypersensitive C-reactive protein (hs-CRP), endothelin-1 (ET-1), and dimethylarginine (ADMA) in patients with essential hypertension. 

Methods: From July 2018 to July 2019, 98 patients with essential hypertension who were treated in the cardiovascular department of our hospital were selected as the study group. Forty healthy people who were examined in the physical examination center of our hospital were selected as the control group. The levels of FKN, hs-CRP, ET-1, and ADMA were detected using an enzyme-linked immunosorbent assay (ELISA) and high-performance liquid chromatography (HPLC), respectively. The levels of FKN, hs-CRP, ET-1, and ADMA at admission were compared between the two groups; the differences of blood pressure between the two groups were compared; the relation between FKN and systolic blood pressure, diastolic blood pressure, hs-CRP, ET-1, and ADMA was analyzed by a Pearson correlation. 

Results: FKN, hs-CRP, ET-1, and ADMA in the study group were significantly higher than those in the control group (P<0.01). The mean systolic pressure and diastolic pressure in the study group were higher compared to the control group (P<0.01). Pearson correlation analysis showed that FKN was positively correlated with systolic (r = 0.705, P < 0.01) and diastolic (r = 0.425, P<0.01) blood pressure. FKN was positively correlated with hs-CRP (r=0.341, P<0.01), ET-1 (r=0.468, P<0.01), and ADMA (r=0.442, P<0.01). 

Conclusion: The serum FKN level of patients with essential hypertension was higher than that of healthy people and was positively correlated with systolic blood pressure, diastolic blood pressure, hs-CRP, ET-1, and ADMA levels. FKN can be used as an effective index for the detection, evaluation, and treatment of essential hypertension.