CORRELATION BETWEEN HCY, MCP-1, AIP, AND CAROTID ARTERY INTIMA-MEDIA THICKNESS IN PATIENTS WITH H-TYPE HYPERTENSION

Yuanping Zhao¹, Guangren Gao², Ying Xue³, Qianqian Gu¹, Yanan Cui³, Shaoqing Li⁴, Jingrui Qi¹, Jun Zhang^{2, *}

¹Department of Gerontology, Cangzhou Central Hospital, Cangzhou Teaching Hospital of Tianjin Medical University, China - ²Department of Cardiology, Cangzhou Central Hospital, Cangzhou, China - ³Department of Ultrasonography, Cangzhou Central Hospital, Cangzhou, China - ⁴Department of Endocrinology, Cangzhou Central Hospital, Cangzhou, China

Objective: To explore the relationship between serum homocysteine (HCY), monocyte chemoattractant protein-1 (MCP-1), plasma arteriosclerosis index (AIP), and carotid artery intima-media thickness (IMT) in patients with H-type hypertension. 

Methods: From January 2018 to February 2020, 64 patients with H-type hypertension who were treated in our hospital’s Department of Cardiology were randomly selected, as well as 64 healthy subjects who underwent physical examinations in our hospital during the same period. The basic clinical data of the 2 subject groups were compared. Fluorescence polarization immunoassay was used to measure serum HCY level; the enzyme-linked immunosorbent method was used to measure MCP-1 level; and AIP was calculated as follows: AIP = log(triglyceride/high-density lipoprotein). A Doppler ultrasonic detector was used to detect IMT. Pearson correlation was used to analyze the correlation between IMT and HCY, MCP-1, AIP, and plaque score in patients with H-type hypertension. 

Results: There was no significant difference between the groups in basic data such as age, gender, body mass index, smoking history, drinking history, and family history (P>0.05), though the blood pressure of the study group was significantly higher than that of the control group (P<0.01). Compared with the control group, the HCY, MCP-1, AIP, IMT, plaque score, and plaque formation rate of the study group were significantly elevated (P < 0.01). Pearson correlation analysis showed that IMT in patients with H-type hypertension was significantly positively correlated with HCY, MCP-1, AIP, and plaque scores (P<0.05). 

Conclusion: The levels of HCY, MCP-1, AIP, and plaque were significantly increased in patients with H-type hypertension and significantly correlated with IMT.