APPLICATION OF HEMOPERFUSION COMBINED WITH PYRALOXIME IODIDE IN EMERGENCY TREATMENT OF PATIENTS WITH ACUTE ORGANOPHOSPHORUS POISONING AND ITS EFFECT ON HEPATIC AND KIDNEY FUNCTION

Guilan Lu^{1, #}, Meifang Zhang^{2, #}, Pengfei Xiao³, Xiulan Liu¹, Ling Shang^{1, *}

¹Department of Emergency, Hunan Provincial Brain Hospital, Changsha, 410007, Hunan Province, China - ²Department of Gastroenterology, Hunan Provincial Brain Hospital, Changsha, 410007, Hunan Province, China - ³Department of oncology, Hunan Provincial Brain Hospital, Changsha, 410007, Hunan Province, China

Objective: To explore the application of hemoperfusion (HP) combined with pyraloxime iodide (PI) in emergency treatment of patients with acute organophosphorus poisoning and its effect on hepatic and kidney function. 

Methods: According to the object screening criteria in this study, 88 patients with acute organophosphorus poisoning treated in the emergency department of our hospital (January 2019 - January 2021) were selected and divided into the PI group and PI+HP group according to the treatment methods, with 44 cases each, so as to compare their clinical efficacy. 

Results: No statistical between-group differences in patients’ general information were observed (P>0.05); the marked effective rate and total effective rate of the PI+HP group were significantly higher than those of the PI group (P<0.05); 6 h, 12 h and 24 h after treatment, the PI+HP group obtained significantly higher serum cholinesterase (CHE) levels than the PI group (P<0.05); after one week of treatment, the PI+HP group obtained significantly lower levels of alanine aminotransferase (ALT), aspartate transaminase (AST) and total bilirubin (Tbil) indicators than the PI group (P<0.05); after treatment, renal function indicators such as serum creatinine (Scr) and blood urea nitrogen (BUN) in patients of the PI+HP group were obviously lower than those of the PI group (P<0.05); during treatment, the patients in both groups suffered from damage to important organs, intermediate syndrome, and rebound, but the incidence rates were significantly lower in the PI+HP group than in the PI group (P<0.05). 

Conclusion: In the emergency treatment of patients with acute organophosphorus poisoning, applying HP combined with PI can obviously enhance the clinical efficacy and effectively promote the recovery of hepatic and renal function in patients.