EXPRESSION AND CLINICAL SIGNIFICANCE OF KERATINOCYTE GROWTH FACTOR RECEPTOR AND TISSUE FACTOR PATHWAY INHIBITOR-2 IN CERVICAL CANCER TISSUE

Hengfen Hu^{1, *}, Qihui Zhao¹, Na Jiang¹, Yanqing Xiao²

¹Affiliated hospital, Hunan Environment Biological Polytechnic, Hengyang, China, 421005 - ²Department of Gynecology, Hengyang Maternal and Child Health Hospital, Hengyang, China, 421001

Objective: To study the expression and clinical significance of keratinocyte growth factor receptor (KGFR) and tissue factor pathway inhibitor-2 (TFPI-2) in cervical cancer tissues. 

Methods: A retrospective analysis of 45 cervical cancer patients admitted to our hospital from January 2020 to December 2021 was used as the observation group, and 45 healthy cervical patients in our hospital during the same period were selected as the control group. The KGFR, TFPI- 2 Positive rate, pathological features, and correlation with cervical cancer. 

Result: The positive rate of KGFR in the observation group was 0.00% lower than that in the control group (84.44%), and the positive rate of TFPI-2 was 100.00% higher than that in the control group (26.67 %). There were significant differences between KGFR positive and cervical cancer TNM stage and degree of differentiation; there were significant differences between TFPI-2 positive expression and cervical cancer TNM stage, degree of differentiation, and lymph node metastasis. The expression level of KGFR was positively correlated with the poor prognosis of cervical cancer, and the expression level of TFPI-2 was negatively correlated with the poor prognosis of cervical cancer. 

Conclusion: The expression of KGFR is upregulated, and the expression of TFPI-2 is downregulated in cervical cancer tissue. The expression levels of the two are directly related to the poor prognosis of cervical cancer patients, and there is a certain correlation with the incidence of cervical cancer.