PROGNOSTIC VALUE OF SERUM HUMAN CARTILAGE GLYCOPROTEIN 39 AND GOLGI PROTEIN 73 IN LIVER CANCER PATIENTS TREATED WITH INTERVENTIONAL THERAPY

Jinpeng Fu^*, Gang Zheng, Rui Wang

Department of Interventional Radiology, Daqing Oil Field General Hospital, Daqing City, Heilongjiang Province, China-163001

Introduction: The aim of the present study was to evaluate the prognostic value of serum human cartilage glycoprotein 39 (YKL-40) and golgi protein 73 (GP73) levels in liver cancer patients treated with interventional therapy.

Materials and method: One hundred and one patients with liver cancer received interventional therapy and were followed up for three years. According to the follow-up results, all patients were divided into a survival group and a death group. Serum YKL-40 and GP73 levels were measured. Prognosis value of serum YKL-40 and GP73 for patients before interventional therapy was evaluated by calculating the area under the receiver operating characteristic (ROC) curve (AUC). 

Results: One week after the first interventional therapy, levels of serum YKL-40 and GP73 in patients were lower than those before interventional therapy (both P<0.001). Pearson correlation analysis revealed that there was a positive correlation between serum YKL-40 and GP73 levels in patients before interventional therapy (r=0.686, P<0.001). Before interventional therapy, serum YKL-40 and GP73 levels in death group were higher than those in the survival group (P<0.001 and P=0.002, respectively). The AUC of serum YKL-40 before interventional therapy was 0.882 (95% CI: 0.819-0.946), higher than AUC of serum GP73 before interventional therapy, which was 0.733 (95% CI: 0.629-0.836) (P<0.001).

Conclusion: Serum YKL-40 and GP73 are closely related to the prognosis of liver cancer patients treated with interventional therapy. Compared with serum GP73 before interventional therapy, serum YKL-40 before interventional therapy may have a higher predictive value for the prognosis of this patient treated with interventional therapy.