INFLUENCING FACTORS FOR DEPRESSION AND ANXIETY AMONG PATIENTS AND EFFECTS ON SHORT-TERM PROGNOSIS AFTER CARDIOVASCULAR INTERVENTIONAL TREATMENT

Wei Qi, Yanxia Wang, Meijun Wang, Guangyu Ma, Caijie Li^*

Department of Cardiovascular Medicine, Second Affiliated Hospital of Qiqihar Medical College, Qiqihar 161006, Heilongjiang Province, China

Introduction: Coronary heart disease (CHD) is a very common ischemic cardiovascular disease and the leading cause of death among patients with cardiovascular diseases. This research was conducted to investigate percutaneous coronary intervention (PCI) for short-term and the influencing factors for depression and anxiety among coronary heart disease (CHD) patients. 

Materials and methods: the clinical data on 90 CHD patients undergoing PCI were included for 1-year follow-up. Patient health questionnaire-9 (PHQ-9) and generalized anxiety disorder-7 (GAD-7) scales were employed for scoring and grouping. They were enrolled into normal group (51 cases) and depression and anxiety syndromes (DAS) group (39 cases). The differences in cardiopulmonary functions and oxygen uptake after treatment were compared. Binary Logistic and COX proportional hazards models were utilized to analyze the influencing factors for postoperative anxiety, depression, and prognosis. 

Results: PHQ-9 and GAD-7 scores of DAS group rose, while 6-min walking distance, left ventricular end diastolic diameter (LVEDd), and anaerobic threshold oxygen uptake declined versus those of normal group (P<0.05). Incidence of major adverse cardiovascular events (MACE) of DAS group was relatively higher (P<0.05). Female, body mass index (BMI), junior college degree and below, various medical histories, and two or more stents were the independent risk factors for postoperative anxiety and depression. Anaerobic threshold oxygen uptake ≥40% was the protective factor (P<0.05). 

Conclusion: age ≥60, various medical histories, two or more stents, left ventricular ejection fraction (LVEF) between 50% and 70%, LVEDd≥50 mm, and postoperative anxiety and depression were the independent risk factors for MACE (P<0.05). After PCI, the incidence of anxiety and depression was high and the prognosis was poor.