IMMUNE-RELATED LONG NON-CODING RNAS SERVE AS POTENTIAL INDICATORS FOR PREDICTING THE PROGNOSES AND IMMUNE LANDSCAPE IN HUMAN LUNG ADENOCARCINOMA

Yangrong Zhong^#,1,3,4, Jilai A^{#, 2}, Chongjun Zhong¹, Yiming Xu^{*, 1}

¹Department of Thoracic Surgery, Affiliated Hospital 2 of Nantong University, Nantong City No 1 People's Hospital, Nantong 226001, China - ²Department of Thoracic Surgery, Shanghai Putuo District Central Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China - ³School of Medicine, Nantong University, Nantong 226001, Jiangsu, P.R. China - ⁴Department of Thoracic Surgery, Affiliated Haian Hospital of Nantong University, Haian 226600, Jiangsu, P.R. China

Immune-related long noncoding ribonucleic acids (irlncRNAs) seemed to play a critical role in predicting the survival of patients with lung adenocarcinoma (LUAD). Herein, we highlighted to excavating an irlncRNAs signature to calculate the prognostics role of these irlncRNA without specific expression level in LUAD patients. In total, the signature, constituted by the 17 paired irlncRNA regardless of accurate expression levels, highlighted a novel prognostic predictive value and immunotherapeutic response in human LUAD. Optimization of paired irlncRNAs for individualized treatments of LUAD patients might act as a vital prognostic indicator for and displayed a comprehensive immune landscape.