EFFECTS OF PROBIOTICS ON CLINICAL EFFICACY, CELLULAR IMMUNE FUNCTION AND SAFETY IN CHILDREN WITH ANTIBIOTIC-ASSOCIATED DIARRHEA

Ying Tang, Ling Chen, Xiao Feng, Fanglin Yang^* 

Department of Pediatrics, Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361003, China

Objective: To investigate the effect of probiotics on clinical efficacy, cellular immune function and safety in children with antibiotic-associated diarrhea (AAD).

Methods: 100 children with AAD diagnosed and treated in our hospital were randomly divided into control group (CG) (n=50) and observation group (OG) (n=50). The patients in the CG were treated with montmorillonite powder, and the patients in the OG were treated with Clostridium butyricum live bacteria capsule combined with montmorillonite powder. The clinical efficacy, immune function index, inflammatory factors, intestinal flora and the incidence of complications were compared between the two groups.

Results: The effective rate of the OG was raised than that of the CG (P<0.05). Before treatment, the immune function, inflammatory factors level, and intestinal flora between two groups were no difference, but after treatment, the levels of IgA, IgM, IgG, Bifidobacterium and Lactobacillus in the OG were raised than those in the CG, and the level of serum IFN- γ in the OG was reduced than that in the OG (P<0.05), while the levels of serum IL-4, IL-10, Enterococcus faecalis and Escherichia coli in the OG were raised than those in the CG (P<0.05). The total incidence of adverse reactions between the two groups was no difference (P>0.05).

Conclusion: The use of probiotics in the treatment of children with AAD has a good clinical effect, which is beneficial to improve the immune function, reduce the inflammatory reaction and improve the intestinal flora of the patients. the therapeutic effect is safe and effective.