CHANGES OF HA AND NLR IN PERIPHERAL BLOOD AFTER ONSET OF ACUTE SPONTANEOUS CEREBRAL HEMORRHAGE AND THE VALUE OF COMBINED DETECTION IN EVALUATING PROGNOSIS OF PATIENTS

Songlin He, Hailong Liu, Zelin Jing, Mingtao Xu, Bo Chen, Baoyuan Sun^*

Department of Neurosurgery, Hohhot First Hospital, Hohhot 010000, Inner Mongolia Autonomous Region, China

Objective: To observe the changes of hyaluronic acid (HA) and neutrophil/lymphocyte ratio (NLR) in peripheral blood after acute spontaneous intracerebral hemorrhage (AICH) and the value of combined detection in evaluating the patient prognosis. 

Methods: 102 patients with spontaneous intracerebral hemorrhage (sICH)admitted to our hospital from May 2015 to March 2017 were selected as the observation group. According to the Rankin Revised Scale, 63 patients with a score less than 3 (including 3 points) were the group with good prognosis, and 39 patients with a score greater than 3 were the group with poor prognosis. 100 normal subjects were selected as the control group. The National Institutes of Health Stroke Scale and Glasgow Coma Index Scale were used to evaluate the treatment of patients with poor prognosis and good prognosis. Serum HA levels were detected by ELISA, neutrophils and lymphocytes were detected by flow cytometry, and NIR levels were calculated. We compared the levels of HA and NLR in peripheral blood of each group. Logistic regression analysis was used to evaluate the relationship between HA and NLR in peripheral blood and prognosis of patients with sICH. The prognostic value of HA and NLR in patients with sICH was evaluated by ROC curve analysis. 

Results: The levels of HA and NLR in the group with poor/good prognosis were higher than control group, meanwhile those in the group with good prognosis were lower than poor prognosis group (P<0.05). The NIHSS score in the group with good prognosis was lower than poor prognosis group, and the GCS score was higher than poor prognosis group (P<0.05). The average volume of hematoma in the good prognosis group was 56.79+8.67 mL, which was smaller than that in the poor prognosis group (91.28+15.96 mL) (P<0.05). Logistic regression model results showed that NIHSS score, GCS score, HA and NLR were significantly correlated with prognosis (P<0.05). The detection of HA and NLR in peripheral blood alone or in combination has high diagnostic value in evaluating the prognosis of patients with sICH. 

Conclusion: The levels of HA and NLR in patients with sICH are raised than those in healthy people, and those may be a poor prognostic factor in patients with acute sICH. The detection of HA and NLR in peripheral blood alone or in combination has high diagnostic value in evaluating the prognosis of patients with sICH.