CHANGES AND CLINICAL SIGNIFICANCE OF SERUM MATRIX METALLOPROTEASE-9, FIBRINOGEN, AND NEUROGLOBIN IN PATIENTS WITH INTRACRANIAL ANEURYSM

Man Yin¹, Sha Yi¹, Xiaoqing Quan¹, Yu Hu^2*

¹Operation Anesthesia Center, Shangjin Nanfu Hospital, Chengdu City, Sichuan Province, China-611700 - ²Neurosurgery department, West China Hospital-Sichuan University, Chengdu City, Sichuan Province, China-610041

Objective: The objective of this study was to investigate the relationship between serum matrix metalloprotease-9 (MMP-9), fibrinogen (FBG), neuroglobin (NGB) and ruptured intracranial aneurysm, and analyze their possibility as an indicator to evaluate the effect of interventional embolization in patients with ruptured cerebral aneurysm.

Methods: One hundred and fifty patients with intracranial aneurysm were selected as research subjects. According to the rupture of intracranial aneurysm, the 150 patients were divided into ruptured group (n=60) and unruptured group (n=90). Ruptured group were treated with interventional embolization. Serum MMP-9, FBG and NGB levels were detected. 

Results: Hypertension, Hunt gradeⅠ-Ⅱ, and Hunt grade III-IV were significantly different between the ruptured group and unruptured group (P=0.045, P<0.001 and P<0.001, respectively). Levels of serum MMP-9, FBG and NGB in rupture group before treatment were higher than those in an unruptured group before treatment (all P < 0.001). Levels of serum MMP-9, FBG and NGB in the ruptured group after treatment were lower than those before treatment (all P < 0.001). Pearson correlation analysis showed that there was a positive correlation between serum MMP-9 and FBG, MMP-9 and NGB, FBG and NGB in a ruptured group before treatment and after treatment.

Conclusions: Serum levels of MMP-9, FBG and NGB in patients with intracranial aneurysm are abnormally increased, and the contents of MMP-9, FBG and NGB are related to the rupture of intracranial aneurysm. These three markers may be used as an indicator to evaluate the efficacy of interventional embolization in patients with ruptured intracranial aneurysm.