Min Shi1, Mingming Shui2, *


1Department of Gastrointestinal Surgery, Wuhan First People's Hospital, Wuhan 430000, Hubei, China - 2Department of Imaging, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, Hubei, China


Introduction: chronic obstructive pulmona-ry disease (COPD) is a common and frequently-occurring respiratory disease. This work aimed to explore the effects of omeprazole and comprehensive nursing intervention on chronic obstructive pulmonary disease (COPD) with gastroesophageal reflux disease (GERD). 

Material and method: a total of 150 COPD patients were divided into three groups (groups A, B, and C with 50 cases in each group) for analysis the diagnostic effects omeprazole. Meanwhile, 50 COPD patients with GERD were divided into two groups (groups D and E with 25 cases in each group) for exploring the effects of comprehenaive nursing intervention. The symptom score, symptom frequency grade, decline rate, diagnostic sensitivity, specificity, coincidence rate, psychological state (self-rating anxiety scale (SAS) and self-rating depression scale (SDS)), and nursing satisfaction were observed and compared. 

Result: the results showed that the reflux symptom scores decreased by (11.2±6.1) points, (9.5±5.7) points, and (11.9±5.4) points in groups A, B, and C, and the decrease rates were (33.2±35.8) %, (34.5±34.1) %, and (16.7±29.5) %, respectively. The standard omeprazole test with a symptom score decrease of 2 had the best diagnostic value for GERD. After nursing intervention, the SAS and SDS scores in the group E (41±8 and 39±8, respectively) were lower than those in the group D (54±9 and 52±9, respectively), showing statistically significant differences (p<0.05). The nursing satisfaction in the group D (64%) was lower than that in the group E (96%), showing p<0.05. 

Conclusion: omeprazole test was a reliable method for the clinical diagnosis of COPD with GERD. Comprehensive nursing intervention could improve the psychological state of GERD patients and help to alleviate the clinical symptoms of patients.


Omeprazole test, gastroesophageal reflux disease, comprehensive nursing intervention, psychological state, diagnosis.