THE CHARACTERISTIC OF LIVER INFLAMMATION IN PATIENTS WITH METABOLIC-(DYSFUNCTION) ASSOCIATED FATTY LIVER DISEASE IN DIFFERENT SUBTYPES

Yu Wang¹, Zi-yu Liu¹, Ming-jia Dai², Fang Ji², Jian-zhong Li¹, Rui-Huang³, Chao Wu³, Xuebing Yan^{2, *}

¹Department of Infectious Disease, Xuzhou Medical University, Xuzhou, Jiangsu, China - ²Department of Infectious Disease, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China - ³Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China

Background and aims: This study aimed to compare the difference on liver inflammation among subgroups in metabolic-(dysfunction) associated fatty liver disease (MAFLD).

Methods: A cross-sectional study of 1335 Chinese patients who underwent ultrasonography with MAFLD involved a cohort from a health screening program. The anthropometric parameters and clinical data of different MAFLD subtypes were compared through the Kruskal-Wallis H test. Univariate linear regression, stepwise multiple regression analysis and collinearity diagnositics were used to analyze the Influencing factors. Liver inflammation was assessed based on the inflammation indicators.

Results: The median age was 44 years, and 841 (63%) patients were male. There was significant difference among four MAFLD subgroups (Group1, 2, 3, and 4) in age, sex, BMI, GGT, TG, HDL, PLT, FPG, AST-to-ALT, and blood pressure (p<0.05). The level of TG (B=3.167, 95%CI: 1.141~5.193, p=0.002), HDL (B=20.145, 95%CI: 7.11~33.181, p=0.003), FPG (B=4.073, 95%CI: 2.254~5.893, p<0.001), and WC (B=0.614, 95%CI: 0.186~1.041, p=0.005) were positive paralleled by the serum GGT in MAFLD patients.

Conclusion: There was statistical difference in serum GGT among different subtypes in MAFLD, which may play a key role in the oxidation stress in the progression of MAFLD. The abdominal obesity and metabolism abnormalities may be association with serum GGT.