Jian Wang1, Lingxiang Liu2, Guoqing Wang3, Xiaoguang Mi4, Xingxing Yin5, Mengting Shao6, Jia Fan7, Yiqian Liu2,# Ling Zhang8, #
1Department of Oncology, Wuxi Second Geriatric Hospital, Wuxi, 214174, Jiangsu, China - 2Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China - 3Department of Traditional Chinese Medicine, The Fifth People's Hospital of Changshu, Changshu 215500, China - 4Department of Respiratory Medicine, The Fifth People's Hospital of Changshu, Changshu 215500, China - 5Department of Functional Inspection, The Fifth People's Hospital of Changshu, Changshu 215500, China - 6Department of Medical Oncology, The Fifth People's Hospital of Changshu, Changshu 215500, China - 7Department of General Medicine, Changshu First People's Hospital Affiliated to Soochow University, Changshu 215500, China - 8Department of Oncology, Jintan Hospital Affiliated to Jiangsu University, Changzhou, 213200, China
Objective: Platelet distribution width (PDW) and platelet count (PC) are frequently investigated platelet parameters in blood routine examination. We aimed to investigate the association of PDW and PC with the prognosis of patients with advanced non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy.
Methods: Retrospective study analyzed 578 NSCLC patients who received platinum-based chemotherapy. Receiver operating characteristic (ROC) curve analysis estimated the optimal cut-off values of PDW and PC. Univariate and multivariate Cox regression analysis evaluated the influence of prognostic factors on prognosis.
Results: ROC curve showed that optimal cut-off values of PDW and PC were 15.25 and 243. Squamous cell carcinoma, low differentiation, and high PDW were independent prognostic factors for poor PFS. Besides, low KPS score, squamous cell carcinoma, low differentiation, no mutation or unknown EGFR, high PDW, and high PC were independent risk factors for OS in NSCLC patients. When PC and PDW parameters were replaced by the coefficients of platelet count and PDW index (coPDW-PC) in multivariate analysis, the results revealed that a high coPDW-PC index was an independent risk factor for poor OS.
Conclusion: A high coPDW-PC index may serve as a potential predictor of poor survival in advanced NSCLC patients receiving platinum-containing chemotherapy.
PDW, PC, NSCLC, platinum-containing chemotherapy, prognostic value.