OBSERVATION OF EFFICACY AND PATHOLOGY IN TREATMENT OF ORTHOPEDIC TENSIVE WOUND BY CONTINUOUS RELAXATION SUTURE WITH NITINOL-NICKEL SHAPE MEMORY ALLOY SUTURE LINE

Changshuang Bai¹, Shuo Jin², Zhuo Li³, Zengxin Li¹, Xiumei Zhang⁴, Jianping Guo^{1, *}

¹Orthopedic Second Treatment Area, Affiliated Hospital of Beihua University, Jilin, Jilin132011, China - ²Hand and foot surgery, Affiliated Hospital of Beihua University, Jilin, Jilin132011, China - ³Department of Orthopaedics, Jilin Longtan District People's Hospital, Jilin, Jilin132021, China - ⁴Electric consulting room, Jilin Second People's Hospital, Jilin, Jilin132001, China

Objective: To explore the efficacy in the treatment of orthopedic tensive wound by continuous relaxation suture line with nitinol-nickel shape memory alloy suture line and observe the resulting pathological change in wounds, thereby providing novel insights into the treatment of orthopedic tensive wound.

Methods: A total of 165 subjects who visited Affiliated Hospital of Beihua University between September 2015 and September 2020 were recruited into this study and divided randomly into 5 groups: Group A (General suture line), Group B (Knot-free absorbable suture line), Group C (steel suture line), Group D (PROLINE suture line) and Group E (nitinol-nickel shape memory alloy suture line), with 35 patients in each group. Then, we assessed the following items in patients of 5 groups: pathological changes, wound closure time, inflammatory factors, anti-oxidative function and endothelial functions. 

Results: Prior to the treatment, we noted the hyperplasia in the collagen fiber hyperplasia in squamous epithelium, with mesenchymal inflammation, while after treatment, gradual reduction was observed in the collagen fiber hyperplasia, with mitigation in mesenchymal inflammation, and the changes in the Group E were more obvious than any other groups. Before treatment, no statistical significance was found in comparison of the levels of CRP, IL-6, PCT, MDA, SOD, ET and NO in serum of patients among 5 groups (P>0.05), but after treatment, levels of CRP, IL-6, PCT, MDA and ET in serum of patients in Group E were much lower than other groups, while SOD and NO were much higher (P<0.05). Besides, following the treatment, patients in Group E had shorter wound closure time as compared to those in other groups (P<0.05). 

Conclusion: Continuous relaxation suture with nitinol-nickel shape memory alloy suture line can mitigate the inflammation to promote the wound closure in the treatment of orthopedic tensive wound. Thus, it can be promoted and applied in clinical practice.