Xiaowu Pi, Hao Huang, Chen Gong, Feng Guo, Yang Wang, Ying Xiong*
The First Affiliated Hospital of Yangtze University, Jingzhou, 437500, China
Long non-coding RNAs are multifunctional regulators of physiological and pathological processes with four recognized typical functions: signaling, baiting, guiding, and scaffolding. They interact with RNA-DNA and RNA-protein to regulate gene expression. An increasing number of studies have linked lncRNA dysregulation to several human diseases. Evidence suggests that multiple lncRNAs are aberrantly expressed in prostate cancer (PC) and can regulate PC progression and metastasis, especially under abnormal conditions. LncRNA is expressed abnormally and regulates progression and metastasis in PC. This paper reviews recent advancements in the study of lncRNAs regarding the regulation of multiple functions in PC, as well as interactions at different molecular levels through epigenetic, transcriptional, and post-transcriptional levels to influence PC metastasis and progression. The biological functions of lncRNAs in PC metastasis are further reviewed and the roles of lncRNAs in PC metastasis (signaling pathways, epithelial-mesenchymal transition, and mesenchymal-epithelial transition, angiogenesis, resistance induction, and neuroendocrine regulation) and possible applications in the clinical diagnosis, prevention, and treatment of PC are elucidated.
Prostate cancer, metastatic, long non-coding RNA, epithelial-mesenchymal transition, diagnosis, neuroendocrine PC.