APPLICATION VALUE ANALYSIS OF PERIPHERAL BLOOD NF-ΚB, RDW AND MMP-9 IN PATIENTS WITH ACUTE CEREBRAL HEMORRHAGE AFTER ATTACK AND PROGNOSIS EVALUATION

Weiwei Wang, Zhang Guo, Dahua Xie, Zhiyong Lin, Ruisheng Lin^*

Department of Neurosurgery, Zhangzhou Hospital Affiliated to Fujian Medical University, Zhangzhou 363000, Fujian Province, China

Objective: To investigate the application value of peripheral blood nuclear transcription factor-кB (NF-кB), red blood cell distribution width (RDW), and matrix metalloproteinase-9 (MMP-9) in patients with acute cerebral hemorrhage after attack and prognosis evaluation. 

Methods: A total of 120 patients with acute cerebral hemorrhage who received diagnosis and treatment in our hospital from January 2020 to December 2021 were selected as the acute cerebral hemorrhage group, and 60 healthy people who underwent physical examination in our hospital during the same period were selected as the healthy control group. In addition, according to the National Institutes of Health Stroke Scale (NIHSS), the patients in the acute cerebral hemorrhage group were divided into mild neurological deficit group (n=42), moderate neurological deficit group (n=38) and severe neurological deficit group. In the functional impairment group (n=40), the patients were divided into a good prognosis group (n=85) and a poor prognosis group (n=35) according to the modified Rankin rating scale (MRS). The levels of NF-κB, RDW and MMP-9 in peripheral blood of different groups were compared. In addition, Pearson's method was used to analyze the correlation between the levels of NF-κB, RDW and MMP-9 with the degree of neurological deficit and prognosis in patients with acute cerebral hemorrhage. 

Results: The levels of NF-κB, RDW, and MMP-9 in peripheral blood of patients with acute cerebral hemorrhage were significantly higher than those in the healthy control group (P<0.05). The levels of NF-кB, RDW and MMP-9 in peripheral blood of patients with acute cerebral hemorrhage in moderate neurological deficit group were significantly higher than those in mild neurological deficit group (P<0.05). The levels of RDW and MMP-9 were significantly higher than those in the mild and moderate neurological deficit groups (P<0.05). The levels of NF-κB, RDW and MMP-9 in peripheral blood of patients with acute cerebral hemorrhage in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05). The levels of NF-κB, RDW and MMP-9 in patients with acute cerebral hemorrhage were positively correlated with NIHSS score and Mrs score (P<0.05). 

Conclusion: The levels of NF-κB, RDW and MMP-9 in peripheral blood of patients with acute cerebral hemorrhage are significantly increased after the onset of acute cerebral hemorrhage. The condition and prognosis of patients with acute cerebral hemorrhage have certain clinical diagnostic value.