Huanli Luo*, Huanling Luo, Rongfang Zhang


Department of Nursing, Henan Vocational College of Nursing, Anyang 455000, Henan Province, China


Objective: To explore peripheral blood β-Correlation between CrossLaps, EMMPRIN levels and disease severity in postmenopausal patients with rheumatoid arthritis. 

Methods: 89 patients with postmenopausal rheumatoid arthritis treated in the rheumatology and Immunology Department of our hospital from October 2019 to November 2020 were selected as the case group of this experiment; 56 healthy postmenopausal women in the physical examination center of our hospital were selected as the control group. According to the disease activity score (DAS28), the disease severity was divided into 35 cases in the low activity group, 28 cases in the moderate activity group and 26 cases in the high activity group. The general data and knee motion of different groups were compared, and the expression differences of β-Crosslaps, IL-6 and EMMPRIN in peripheral blood of different groups were studied, and the correlation between the above indicators and the severity of disease was analyzed. 

Results: Compared with moderate and low activity groups, the levels of β-Crosslaps and IL-6 in peripheral blood of high activity group were significantly increased (P<0.05); compared with the medium and low activity groups, the knee mobility of the high activity group decreased significantly (P<0.05); compared with the medium and low activity groups, the EMMPRIN level of the high activity group increased significantly (P<0.05); according to the Pearson correlation test, the knee mobility and peripheral blood β- CrossLaps, serum IL-6 and EMMPRIN showed a positive correlation (P<0.05). 

Conclusion: Peripheral blood β-CrossLaps, IL-6 and EMMPRIN are highly expressed in postmenopausal RA patients. The more serious their condition is, the smaller their knee joint activity is, and the more serious their condition is.


Peripheral blood β-Crosslaps, EMMPRIN, postmenopausal rheumatoid arthritis, disease severity, relevance.