EVALUATION OF THE EFFECTS OF MRNA AND INACTIVE COVID VACCINE APPLICATIONS ON THE CLINICAL COURSE OF COVID 19 PATIENTS

Umit Savascı^{1, *}, Tunahan Ayaz¹, Bora Uysal², Deniz Dogan³

¹University of Health Sciences, Gulhane Medical Faculty, Infectious Diseases And Clinical Microbiology, Ankara, Turkey - ²University of Health Sciences, Gulhane Medical Faculty, Department of Radiation Oncology, Ankara, Turkey - ³University of Health Sciences, Chest Diseases, Ankara, Turkey

Objective: As of December 2021, two types of vaccines are applied in our country: inactive Coronavac and BNT162b2 mRNA vaccine. In this study, it was aimed to compare the rates of Covid-19 disease infection, pneumonia development rates and hospitalization requirement of individuals vaccinated with different vaccines.

Materials and methods: Individuals at least one dose vaccinated with Coronavac inactive or mRNA active were compared for the evaluation of oxygen saturation values, SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR) results for the development of pneumonia, and hospitalization.

Results: 71 individuals vaccinated with mRNA vaccine and 145 individuals vaccinated with inactive Coronavac vaccine, a total of 216 individuals were evaluated. There was no significant difference between the two groups in terms of the presence of fever complaints and Sars-CoV-2 Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) positivity rates. 5.6% (n=4) of the individuals vaccinated with the mRNA vaccine had pneumonic infiltration on non-contrast computed tomography (CT) images of the thorax, while 2.8% (n=2) required hospitalization. 17.9% (n=4) of the individuals vaccinated with inactive Coronavac vaccine had pneumonic infiltration on non-contrast thoracic CT images, while 11.7% (n=17) had hospitalization requirement.

Conclusion: There are currently no studies in the literature comparing the effectiveness of an inactive vaccine and an mRNA vaccine. In our study, we concluded that even if people vaccinated with the mRNA vaccine were infected with Sars-CoV-2, the pneumonic involvement and hospitalization requirements for thoracic CT were lower compared to those without the vaccine and those vaccinated with the inactive Coronavac vaccine.