Lili Ding, Haijun Sun*


Department of Critical Care Medicine, Suqian City First People's Hospital, Suqian, 223800, China


Objective: To explore the regulation role of norepinephrine on the mean filling pressure and cardiac output in septic shock patients. 

Methods: 120 septic shock patients,who were treated from June 2020 to May 2022, were included in this experiment. They were divided into experimental group (treated withNE,60 cases) and control group (treated with DA,60 cases). The two groups general clinical data were collected. Cardiac output (CO) and left ventricular ejection fraction (LVEF) were checked by TTE, and PMSF was measured by the 12 s inspiratory retention method. Before and after treatment, the changes, adverse reactions and 28 day survival were compared and analyzed in two groups. 

Results: The effective rates of the two groups were 93.33% and 80.00% in the experimental and control group. Before treatment,there was no difference in CO, LVEF, PMSF, and the adverse reactionsincidencebetween the two groups (P>0.05). After treatment, the CO, LVEF and PMSF of the were raisedin experimental group (P<0.05). The adverse reactions incidenceandthe 28 day mortality of the two groups with no significant difference (P>0.05). 

Conclusion: Norepinephrine can significantly increase mean filling pressure and CO of patients with septic shock, but it does not have a significant effect on improving survival rate. 


Norepinephrine, septic shock, mean filling pressure, Cardiac output.