DIAGNOSTIC VALUE OF SERUM CYFRA21-1, VEGF, AFP, CA19-9 AND SCC IN ESOPHAGEAL CANCER

Jing Jiang^{1, #}, Gang Xiao^{2, #}, Lu Luo¹, Jing Li¹, Junming Hou³, Hui Wei⁴, Dezhen Yang^{5, *}

¹The Fourth Ward of Cancer Hospital, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, Shaanxi Province, Shaanxi Province, China - ²Department of General Surgery, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, Shaanxi Province, China - ³Department of Integrated Traditional Chinese and Western Medicine, Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, Shaanxi Province, China - ⁴Department of Internal Medicine-Oncology, Cancer Hospital, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, Shaanxi Province, China - ⁵Department of Oncology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000

Objective: To investigate serum cytokeratin 19 fragments (CYFRA21-1), vascular endothelial growth factor (VEGF), alpha-fetoprotein (AFP ), carbohydrate antigen 19-9 (CA19-9), and squamous cell carcinoma antigen (SCC) detection of the diagnosis and clinical value of esophageal cancer. 

Methods: From April 2015 to April 2019, 92 cases of patients with esophageal cancer admitted to our hospital were selected as esophageal cancer patients. There were 84 cases of benign esophageal disease group and 88 cases of healthy physical examination in the same period as the control group. Comparison of Three groups of serum CYFRA21-1, VEGF, AFP, CA19-9, SCC levels and the above indicators' levels of esophageal cancer patients in different The receiver operating characteristic curve (ROC curve) was used to evaluate the diagnostic value of five indicators and their combined detection for different TNM staging and with or without lymph node metastasis. The receiver operating characteristic curve (ROC curve) was used to evaluate the diagnostic value of five indicators and their combined detection for esophageal cancer. cancer group was higher than those in the benign esophageal disease group and the control group (P<0.05), while the above-mentioned levels of the There was no statistical significance (P>0.05). The serum levels of five serum indicators in patients with stage III~IV esophageal cancer were higher than those in stage I~II. The serum levels of five patients with lymph nodes The ROC curve showed that the area under the curve (AUC), sensitivity, and specificity for the diagnosis of esophageal cancer were CYFRA21-1 of 0.749, 77.2%, 71.4%, VEGF was 0.852, 82.6%, 85.7%, and AFP was 0.631, 63.0%, 67.9%, CA19 -9 was 0.819, 83.7%, 81.0%, SCC was 0.717, 72.8%, 72.6%; and the five combined diagnoses had an AUC of 0.960, a sensitivity of 90.2%.

Conclusion: The combined detection of serum CYFRA21-1, VEGF, AFP, CA19-9 and SCC can effectively The combined detection of serum CYFRA21-1, VEGF, AFP, CA19-9 and SCC can effectively diagnose esophageal cancer and evaluate the condition, which provides a basis for clinical diagnosis and treatment