CORRELATION OF SERUM CYSTATIN C, INFLAMMATORY FACTORS, FOLIC ACID AND VITAMIN B12 LEVELS WITH CAROTID ARTERY STENOSIS IN PATIENTS WITH ISCHEMIC CEREBROVASCULAR DISEASE

Chuanzhen Qiu^*, Bangming Guo, Yian Ouyang, Shunde Hua, Haibin Wang, Wei Cheng

Department of Neurosurgery, the First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi Province, China

Objective: To explore the correlation between the levels of serum cystatin C (CysC), inflammatory factors, folic acid and vitamin B12.

Methods: From January 2018 to June 2019, 125 patients with ischemic cerebrovascular disease and the degree of carotid artery stenosis. ischemic cerebrovascular disease in our hospital were collected and divided into mild stenosis group (<30%), moderate stenosis group (30%~69%) and Meanwhile, 25 healthy adults in the outpatient department of our hospital at the same stage were collected as the normal stenosis group (<30%), moderate stenosis group (30%~69%) and severe stenosis group (70%~99%). Meanwhile, 25 healthy adults in the outpatient department of our hospital at the same stage were collected as the normal control group, and the serum Cys levels of each group were compared C. The levels of cathepsin S (cat s), folic The levels of cathepsin S (cat s), folic acid, vitamin B12, high sensitivity C-reactive protein (hs CRP), tumor necrosis factor - α (TNF - α) and interleukin-6 (IL-6) were analyzed.

Results: Levels of serum Cys C and cat s in different degree stenosis groups were significantly lower than those in the normal control group (P<0.05). The level of serum Cys C in severe stenosis group and moderate stenosis group was significantly lower than that in mild stenosis group, and the level of cat s in severe stenosis group was significantly lower than that in moderate stenosis group (P<0.05), and the level of cat s in severe stenosis group was significantly lower than that in moderate stenosis group. The levels of folic acid and vitamin S in severe stenosis group was significantly lower than that in moderate stenosis group (P<0.05), and the level of cat s in severe stenosis group was significantly lower than that in moderate stenosis group (P<0.05). The levels of folic acid and vitamin B12 in different stenosis groups were significantly lower than those in normal control group (P<0.05). The levels of folic acid and vitamin B12 in severe stenosis group were significantly lower than those in mild stenosis group (P<0.05), and there was no The levels of folic acid and vitamin B12 in severe stenosis group were significantly lower than those in mild stenosis group (P<0.05), and there was no significant difference between mild stenosis group and moderate stenosis group (P>0.05). The levels of hs CRP, TNF - α and IL-6 in different stenosis groups were significantly higher than those in the normal control group (P<0.05). The levels of hs CRP, TNF - α and IL-6 in moderate stenosis group and severe stenosis group were significantly higher than those in mild stenosis group (P&lt; 0.05). The levels of hs CRP, TNF - α and IL-6 in severe stenosis group were significantly higher than those in moderate stenosis group (P<0.05). The degree of carotid stenosis was negatively correlated with serum Cys C, folic acid and vitamin B12 levels (r=- 0.190, -0.083, -0.290, P<0.05), and positively correlated with the levels of cat s, hs CRP, TNF - α and IL-6 (r=0.168, 0.255, 0.223, 0.159, P<0.05). 

Conclusion: The serum levels of Cys C, folic acid and vitamin B12 in patients with ischemic cerebrovascular disease were significantly decreased, and The levels of cat s and inflammatory factors were significantly increased; the levels of Cys C, folic acid and vitamin B12 were negatively correlated with The levels of Cys C, folic acid and vitamin B12 were negatively correlated with the degree of carotid artery stenosis, and the levels of cat s and inflammatory factors were positively correlated with the degree of stenosis.