ANALYSIS OF THE INFLUENCE OF CIRCADIAN RHYTHM ON EMERGENCY GENERAL ANESTHESIA OPERATION BASED ON THE DIFFERENCE OF DEXMEDETOMIDINE DOSAGE AND SEDATION EFFECT

Jinhui Chen¹, Wei Jin¹, Hua Zhang¹, Fuchao Wang¹, Tongjun Zhang¹, Jianhua Zhao², Xuefei Sun¹, Zhongyi Wang^{1, *}

¹Department of Anesthesiology, Harrison International Peace Hospital, Hengshui, Hebei 053000, China - ²Department of Anesthesiology, Anping County People's Hospital, Hengshui, Hebei 053000, China

Objective: Based on the difference of dexmedetomidine (DEX) dosage and sedation effect, the influence of circadian rhythm on emergency general anesthesia operation was analyzed.

Methods: Total 124 patients who underwent emergency general anesthesia operation in Hengshui People's Hospital from September 2019 to March 2022 were selected and divided into two groups according to different anesthesia time. Group A was anesthetized from 8:00 a.m. to 10:30 p.m., and Group B was anesthetized from 14:00 p.m. to 16:30 p.m. Heart rate (HR), pulse oxygen saturation (SpO₂), bispectral index (BIS), auditory evoked potential index (AAI), observer alertness/sedation assessment scale (OAA/S) score and adverse reaction rate were used as observation indicators to evaluate the influence of the difference in dexmedetomidine dosage and sedation effect on the daily rhythm in emergency general anesthesia surgery.

Results: There was no significant difference in HR and SpO₂ at different time points between the two groups (P>0.05). The BIS, AAI, OAA/S scores and the incidence of adverse reactions (24.19%) of patients in group B at different time points were significantly lower than those in group A (P<0.05).

Conclusion: The daily rhythm can affect the sedative effect of DEX, which is shown that the sedative effect in the afternoon is significantly better than that in the morning, and the dosage of DEX is related to the incidence of adverse reactions, with the dosage of 0.5 μg/kg, the incidence of adverse reactions will be reduced.