VALUE OF SERUM PLT/ALB AND CRP/ALB IN EVALUATING MUCOSAL HEALING AND THE RECURRENCE OF CROHN'S DISEASE

Jingze Li^{1, #}, Xiaoqing Yang^{2, #}, Lang Liu¹, Yilong Sun¹, Yixuan Zhao¹, Xi Tan1, Shuirong Lu^{2, *}

¹Department of Gastrointestinalurology Endoscopy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China - ²Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China

Objective: To explore the value of serological PLT/ALB and CRP/ALB in evaluating mucosal healing and the recurrence of Crohn's disease. 

Methods: A total of 85 patients with Crohn's disease treated in our hospital from April 2017 to April 2019 were selected. According to the clinical and endoscopic healing criteria, the patients were divided into a mucosal healing group and a mucosal non-healing group. General data, serum ALB, PLT, CRP, PLT/ALB and CRP/ALB levels before and after treatment, as well as their correlations with SES-CD score and serum indexes, were compared to evaluate the value of mucosal healing. The patients were divided into recurrent and non-recurrent groups according to whether they relapsed. The levels of serum indexes and the value of serum indexes in predicting disease recurrence were compared between the two groups. 

Results: After treatment, the level of ALB in the mucosal healing group was significantly higher than that in the mucosal non-healing group, while the levels of PLT, CRP, PLT/ALB and CRP/ALB decreased (P < 0.05). Serum ALB, PLT, CRP, PLT/ALB and CRP/ALB were correlated with SES-CD score. The AUC values of ALB, PLT, CRP, CRP/ALB and PLT/ALB were 0.712, 0.662, 0.774, 776 and 719, respectively. After treatment, ALB in the recurrent group was significantly lower than that in the non-recurrent group, while the levels of PLT, CRP, PLT/ALB and CRP/ALB increased (P<0.05). The AUC values of ALB, PLT, CRP, CRP/ALB and PLT/ALB for predicting disease recurrence were 0.641, 0.628, 0.643, 0.652 and 0.651, respectively. 

Conclusion: the combined serum indexes (PLT/ALB and CRP/ALB) have high clinical value in evaluating mucosal healing and the recurrence of Crohn's disease.