Ultrasound Irradiation of Microbubbles on the Permeability of Rat Prostatic Hyperplasia

Bao Zou^1#, Chaoxue Zhang^2#, Xin Liu¹, Xing Chen¹, Weiqiang Cai¹, Cong Wang¹, Fan Jiang^3*

¹Department of Ultrasound Medicine, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan 232000, Anhui Province, China - ²Department of Ultrasound Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, Anhui Province, China - ³Department of Ultrasound Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China

Introduction: Prostatic hyperplasia is an infectious disease of the male reproductive system caused by a variety of factors and is currently treated with drug therapy. Because it is difficult for drugs to reach effective therapeutic concentrations in prostate tissue, ultrasound microbubbles combined with ultrasound irradiation are often used to increase the permeability of prostate hyperplasia tissues, so that the drugs can be fully absorbed. The purpose of this article is to explore the effect of ultrasound irradiated microbubbles on the permeability of rat prostate hyperplasia tissue. 

Materials and methods: With 48 rats as the research object, the rats were divided into the prostate hyperplasia control group and the ultrasound-irradiated microbubble observation group. E. coli was injected into the prostate tissue of the rat to create an animal model of benign prostatic hyperplasia. After successful modeling, a quantitative Evans Blue reagent was injected into the rats, and the rats in the observation group were treated with ultrasound-irradiated microbubbles. The ultrastructural changes of the rat prostate tissue were observed under a microscope. The permeability of the prostate hyperplasia tissue was analyzed according to the amount of Evans blue exudation, and the rat prostate index was calculated. 

Results: The results of the study showed that the exudation concentration of Evans blue in the observation group was (15.8±2.6)×10-8g/L, which was higher than the exudation concentration of Evans blue in the control group (9.3±1.7)×10-8g/L. The prostate index of the observation group was (4.68±0.8), which was significantly higher than that of the control group (2.71±0.6). 

Conclusion: Therefore, it can be seen that ultrasound irradiation of microbubbles can increase the permeability of prostate hyperplasia tissue, thereby improving the drug absorption effect.