Nannan Liu1, 2, #, Dijun Fu1, #, Yixiao Chen1, #, Kaidi Nie1, 2, Jie Wang1, 2, Tingting Deng1, 2, *, Luming Qi1, 2, *, Lina Xia1, 2, *


1School of Health Preservation and Rehabilitation, Chengdu University of TCM, Shierqiao Road, Chengdu, Sichuan, 610075, People’s Republic of China - 2Key Laboratory of Traditional Chinese Medicine Regimen and Health Industry Development, State Administration of TCM, Chengdu, Sichuan, 610075, People’s Republic of China


Introduction: To explore the effect of Liuzijue exercise on blood pressure and oxidative stress of patients with essential hypertension. 

Materials and methods: 41 patients diagnosed with essential hypertension were recruited and randomly divided into Liuzijue exercise group and waiting treatment group, and 15 healthy people were recruited as the healthy group. On the basis of maintaining normal work and rest pattern and continuing the original drug treatment plan, Liuzijue exercise group entered into a 12-week Liuzijue exercise plan, and the waiting treatment group did not have any form of fitness exercise intervention. The two groups and healthy group had blood pressure, superoxide dismutase (SOD), glutathione (GSH), Malondialdehyde (MDA); Glutathione peroxidase (GSH-PX); γ-glutamyl peptide aminotransferase (GGT) levels in blood monitored on the first day and the end of the intervention. 

Results: After the intervention, the SBP and Pulse Pressure in Liuzijue exercise group were significantly decreased(P<0.01), compared with Waiting treatment group, the level of SBP, DBP and Pulse Pressure of Liuzijue group decreased(P>0.05). Compared with the Waiting treatment group, the level of GSH-PX in Liuzijue exercise group was higher (P<0.01), in Liuzijue exercise group, the expression of SOD was higher after intervention. Other indicators had no statistically significant changes (P>0.05). 

Conclusion: The 12-week Liuzijue exercise can enhance antioxidant capacity, improve oxidative stress, reduce systolic and diastolic blood pressure, by increasing the activity of GSH-PX in patients with essential hypertension. 


Essential hypertension, liuzijue exercise, oxidative stress, SOD, GSH-PX.