RELATIONSHIP BETWEEN ISLET CELL ANTIBODY AND Β CELL FUNCTION AMONG CHILDREN WITH DIABETES MELLITUS

Xinxia Zhang^{1, #}, Kunpeng Xu^{2, #}, Na Zhang^{3, *}

¹Department of Nutrition, The Second Affiliated Hospital of Xingtai Medical College, Xingtai, 054000, Hebei Province, China - ²Department of Pediatrics, Clinical Department of Xingtai Medical College, Xingtai, 054000, Hebei Province, China - ³Department of Internal Medicine, Clinical Department of Xingtai Medical College, Xingtai, 054000, Hebei Province, China

The relationship between islet cell antibody (ICA) and β cell function among patients with diabetes mellitus (DM) was investigated. Insulin-dependent diabetes mellitus (IDDM) patients admitted to the endocrinology department of XX hospital were included and divided into DM group (40 cases) and control group (24 cases). ICA and glucose tolerance tests (GTT) were performed. According to the comparison of ICA positive rate between two groups, ICA positive rate of DM group was 40.00% (16/40) and that of control group was 8.33% (2/24). The difference was remarkable (P<0.01). ICA positive fasting and postprandial blood glucose (1, 2, and 3 hours) of DM group were 15.41±4.33, 20.36±5.82, 25.15±6.73, and 23.16±5.54, respectively. Insulin levels among ICA positive patients 1 and 2 hours after meal were all significantly lower than those among ICA negative patients (P<0.05). C-peptide levels among ICA positive patients 1 and 2 hours after meal were both obviously lower than those among ICA negative patients (P<0.05). Besides, glucose areas of ICA positive and negative patients in DM group and patients in the control group were 65.12±17.45, 58.11±16.07, and 19.57±28.33, respectively. Insulin areas of ICA positive and negative patients in DM group and patients in the control group reached 29.12±7.32, 34.51±8.24, and 80.67±24.38, respectively. C-peptide areas of ICA positive and negative patients in DM group and patients in the control group were 0.57±0.44, 0.89±0.52, and 5.71±1.33, respectively. β cell function among ICA positive children with DM was inferior to that among ICA negative children.