PREVENTIVE EFFECT OF FRESH YAM EXTRACT ON GASTRIC ULCERS IN MICE

Qiuxia Wu^{1, *}, Qingsheng Sun²

¹Department of Gastroenterology, Henan Hospital of Traditional Chinese Medicine ( The Second Affiliated Hospital of Henan University of traditional Chinese Medicine), Zhengzhou 450002, PR China - ²Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou 450007, PR China

Objective: The purpose of this article is to study the preventive effect of fresh yam extract on gastric ulcers in mice. By analysing and observing the morphological structure of the gastric mucosa, calculating the ulcer index of gastric ulcers in the mice and observing the expression of malondialdehyde nitric oxide protein in the serum superoxide apparatus, the prevention and treatment of gastric ulcers was explored. 

Methods: The methods included an experimental comparison by randomly dividing 100 experimental mice into a blank control group, a model group, a Teprenone group, a high-dose fresh yam extract group and a low-dose fresh yam extract group. There were a total of five groups, and each group was comprised of 20 mice. In the control and model groups, normal saline was used for intragastric administration, and the remaining three groups were given intragastric administration for 45 days. Afterwards, indomethacin (2.5 mg/mL) was intragastrically administered to the mice in all groups except the blank control group to establish a gastric ulcer model. All mice were sacrificed after the data collection was completed. Stomach tissues were removed and stained for pathological sections to observe changes in the mucosal tissue morphology. Subsequently, the ulcer index was measured, and data such as ulcer inhibition rate and serum protein expression were calculated. 

Results: The analysis indicated that the ulcer inhibition rate of the high-dose fresh yam extract group was 1.63±0.32 mm², the low-dose fresh yam extract group was 3.74±1.36 mm², the Teprenone group was 1.27±0.38 mm² and the model group was 5.73±1.83 mm². 

Conclusion: Fresh yam extract can alleviate gastric ulcers caused by indomethacin, as exhibited by the high-dose fresh yam extract group, the low-dose fresh yam extract group and the Teprenone group. When comparing these groups with the model group, gastric tissue inflammation, cell infiltration and gland damage were less severe. A high dose of fresh yam extract can reduce the expression of MDA and NO in serum and increase the expressions of SOD and GSH-Px (P<0.05).