Fulminant type 1 diabetes with normal serum amylase: a case report

JuYuejun¹, Shen Ting¹, Zhang Shaofeng², Zhou Mengling¹,QuJunchen³, Kong Yinghong^*

¹Department of Endocrinology, Changshu No.2 People's Hospital, Changshu, 215500 - ²Changshu Medicine Examination Institute, Changshu, 215500 - ³Department of Radiology, Changshu No.2 People's Hospital, Changshu, 215500

Fulminant type 1 diabetes (FT1D) is a subtype of type 1 diabetes characterized by abrupt onset, acidosis at diagnosis, negative status of islet-related autoantibodies, and nearly no C-peptide secretion. Our hospital admitted an 18-year-old man who had HbA1c 5.7%, Autoantibodies against pancreatic β cells were negative, serum amylase 92 U/L presented in diabetic ketoacidosis on admission. CT scan of the liver showed localized edema. After two weeks of intensive insulin therapy, his serum and urine amylases were still in the normal range, autoantibodies against pancreatic β-cells were still negative, and abdominal CT showed that the local liver edema disappeared. In this report, a case of fulminating type 1 diabetes with normal serum amylase is concerned.