JuYuejun1, Shen Ting1, Zhang Shaofeng2, Zhou Mengling1,QuJunchen3, Kong Yinghong*


1Department of Endocrinology, Changshu No.2 People's Hospital, Changshu, 215500 - 2Changshu Medicine Examination Institute, Changshu, 215500 - 3Department of Radiology, Changshu No.2 People's Hospital, Changshu, 215500


Fulminant type 1 diabetes (FT1D) is a subtype of type 1 diabetes characterized by abrupt onset, acidosis at diagnosis, negative status of islet-related autoantibodies, and nearly no C-peptide secretion. Our hospital admitted an 18-year-old man who had HbA1c 5.7%, Autoantibodies against pancreatic β cells were negative, serum amylase 92 U/L presented in diabetic ketoacidosis on admission. CT scan of the liver showed localized edema. After two weeks of intensive insulin therapy, his serum and urine amylases were still in the normal range, autoantibodies against pancreatic β-cells were still negative, and abdominal CT showed that the local liver edema disappeared. In this report, a case of fulminating type 1 diabetes with normal serum amylase is concerned.


fulminant type 1 diabetes, Serum amylase, diabetic ketoacidosis.