EVALUATION OF LEFT VENTRICULAR FUNCTION IN PATIENTS WITH FIRST ONSET GRAVES DISEASE BY THREE-DIMENSIONAL SPECKLE TRACKING IMAGING

Yi Xu^{1, #, *}, Songxia Peng^{2, #}, Li Qin², Dianjing Sun¹, Jianlin Geng¹

¹Department of Endocrinology, Harrison International Peace Hospital, Hengshui, Hebei 053000, China - ²Department of Second Ultrasound, Harrison International Peace Hospital, Hengshui, Hebei 053000, China 

Introduction: To evaluate the left ventricular function in patients with first onset Graves Disease by three-dimensional speckle tracking Imaging. 

Materials and methods: A total of 62 untreated Graves' disease patients confirmed in our hospital were selected, including 34 cases in the hyperthyroidism group, 28 cases in the hyperthyroidism heart disease group and 31 cases in the normal control group. The pyramidal three-dimensional model of the left ventricle was obtained by four-chamber apical section. The images were stored and the data were analyzed on the EchoPAC workstation. The overall longitudinal radial and circumferential peak systolic strain (GLS, GRS, GCS) of the left ventricle was measured by three-dimensional speck tracing technique, and the differences among the three groups were compared.

Results: Compared with the control group, GLS, GRS and GCS in the hyperthyroidism group and the hyperthyroidism heart disease group were decreased, with statistical significance (P<0.05). Compared with the hyperthyroidism group, the GLS of patients in the hyperthyroidism heart disease group was decreased, and the difference was statistically significant (P<0.05), while there was no significant difference in GRS and GCS between the two groups (P>0.05). ROC curve analysis showed that GLS has a certain predictive value for hyperthyroidism and hyperthyroidism heart disease.

Conclusion: When the overall systolic function of the left ventricle was still at the normal level in patients with Graves' disease, the overall deformation capacity of the longitudinal myocardium of the left ventricle began to decline earlier than that of the radial and circumferential myocardium.