Ligang Chen1, Hao Lin2, *
1Department of Orthopedics and Traumatology, Sanya Central Hospital, Sanya 572000, Hainan Province, China - 2Department of Orthopedics, Dongxihu District People's Hospital, Wuhan 430040, Hubei Province, China
It was to study the treatment effect of conventional antibiotics and antibacterial dressings in addition to conventional antibiotics on bacterial biofilm infection in postoperative incision of orthopedic trauma patients. Orthopedic patients undergoing post-traumatic surgery were randomly divided into two groups. The patients in the control group were treated with conventional antibiotics after the operation, and those in the experimental group were treated with conventional antibiotics combined with incision antibacterial dressing. The reduction rate of wound volume, the results of bacterial culture, the temperature of wound surface, the pH value of exudate, and the morphological and structural changes of bacterial biofilm on wound surface were observed. Compared with the control group, the wound area of the experimental group was greatly reduced in the reduction rate of wound volume (P=0.000<0.001). In terms of bacterial culture results, the most common pathogens in the experimental group after twelve days of treatment were Staphylococcus aureus, Bronze Monomonas, and Teratobacter singularis, which occurred in 6, 3, and 1 case, respectively. In the control group, Staphylococcus aureus, bronze-green prosthesis, and Enterobacter cloacae were found in 8, 7, and 2 cases, respectively. After twelve days of treatment, the pH of the experimental group was greatly lower than that of the control group (P=0.000 <0.001). In terms of morphological and structural changes of bacterial biofilm on the wound surface, tissue samples were collected from four patients before and twelve days after treatment for microscopic examination, and the morphological and structural changes of bacterial biofilm occurred. The results of the two groups were compared, it was concluded that the addition of antibacterial dressings based on conventional antibiotics was superior to the use of conventional antibiotics alone. It had advantages in promoting wound shrinkage and low positive rate of bacterial culture, and had advantages in microscopic aspects such as improving environmental temperature and pH. Based on laboratory research and analysis, antimicrobial dressings based on conventional antibiotic treatment had a certain antibacterial effect on biofilm infection.
Antibacterial dressings, orthopedic trauma patients, bacterial biofilm, infection.