COMPARISON OF RISK FACTORS BETWEEN PROGRESSIVE ISCHEMIC STROKE AND NON-PROGRESSIVE ISCHEMIC STROKE

Suwei Sun¹, Xia Sun^2*, Hui Gao², Chenxiao Zhu¹ 

¹Department of Critical Care Medicine, The First Affiliated Hospital of Xingtai Medical College (Xingtai First Hospital), Xingtai 054001, Hebei Province, China - ²Department of Emergency, Xingtai People's Hospital, Xingtai 054001, Hebei Province, China

Objective: To analyse the difference in risk factors between progressive and non-progressive ischemic strokes. 

Methods: A total of 120 patients with ischemic stroke were selected from February 2018 to March 2019 in our hospital’s Department of Neurology. Of these, 60 patients with progressive ischemic stroke formed the observation group and 60 patients with non-progressive ischemic stroke formed the control group. The history of all selected patients (diabetes mellitus) was investigated via detailed questionnaires, including hypertension, stroke, coronary heart disease, and personal history (e.g. smoking history and drinking history). Blood lipid (TC, TG, LDL-C, HDL-C, WBC), cholesterol, platelet (PLT), and fibrinogen (FIB) levels were measured. Multivariate logistic regression analysis was used to analyse the risk factors of progressive ischemic stroke. 

Results: The number of patients with diabetes and stroke in the observation group was significantly higher than in the control group (P<0.05); TC, TG, LDL, and fasting blood sugar levels in the observation group were significantly higher than those in the control group (P<0.05), and HDL levels in the observation group were significantly lower than those in the control group (P<0.05). The cholesterol and FIB levels were significantly higher than those of the control group (P<0.05), while PLT levels were significantly lower than those of the control group (P<0.05). The regression analysis showed that diabetes mellitus occurrence, LDL, fasting blood sugar, WBC, FIB, and PLT levels were significantly higher than those of the control group (P<0.05) and may be significant as risk factors for progressive ischemic stroke. 

Conclusion: Patients with diabetes mellitus, stroke, hyperlipidemia and high levels of WBC, cholesterol, and FIB and low PLT levels are at high risk of progressive ischemic strokes; thus, diabetes history, LDL, fasting blood sugar, WBC, FIB, and PLT are all progressive ischemic stroke risk factors.