COMPARISON OF INFLUENCE FACTORS OF THE CONTROL EFFECT OF PRI-MARY HYPERTENSION IN DIFFERENT TERRAIN AREAS

Ying Zheng¹, Mingrong Shao², Yongfu Feng³, Weiying Zhang⁴, Xia Liu^{5, *}

¹Department of ECG and Blood Pressure Research Room, The Third People’s Hospital of Chengdu, Chengdu, Sichuan 610031, PR China - ²Department of Special Inspection Section, Guanghan People's Hospital, Deyang , Sichuan, 618300, PR China - ³Department of ECG, Chengdu Xindu District People's Hospital, Chengdu, Sichuan, 610500, PR China - ⁴Department of ECG, Derong County People's Hospital, Ganzi Tibetan Autonomous Prefecture, 627950, PR China - ⁵Department of Critical Medicine, The Third People’s Hospital of Chengdu, Chengdu, Sichuan 610031, PR China

Introduction: To investigate influence factors of the control effect of primary hypertension in plateau and plain areas and compare their differences, so as to provide more reference for the development of blood pressure control scheme for residents in topographic areas. 

Materials and methods: Patients with primary hypertension treated in hospitals in plateau and plain areas (100 each) from January 2017 to March 2022 were included, and the clinical features and blood pressure control effect of 2 groups were compared. A multivariate logistic regression model was adopted to evaluate independent influence factors of the control effect of primary hypertension in plateau and plain areas. 

Results: There were significant differences in the course of hypertension, heart rate, creatinine, total cholesterol, triglyceride, low density lipoprotein cholesterol, use ratio of angiotensin-converting enzyme receptor inhibitor (ARB), proportion of stroke history, proportion of coronary disease history, proportion of atrial fibrillation history and compliance grading (P<0.05). 24-hour ambulatory mean systolic and diastolic pressure levels in the plateau group were significantly higher than that in the plain group (P<0.05). The blood pressure control rate in the plateau group was significantly lower than that in the plain group (P<0.05). The multivariate logistic regression model analysis showed that an age of 65 or above was an independent protective factor for the control effect of patients with primary hypertension in the plain area (P<0.05). Concurrent hyperuricemia was an independent risk factor for disease control effect (P<0.05), while high compliance was an independent protective factor for the control effect of patients with primary hypertension in the plateau area (P<0.05). 

Conclusion: The blood pressure control effect of patients with primary hypertension in the plateau area is poor. The blood pressure control in the plateau area should pay more attention to compliance, while the blood pressure control in the plain area is closely related to age and uric acid level.