Jingxian Chen*, Jie Sun, Wenhui Fan
Department of Cadre Ward, Maanshan People's Hospital, Maanshan, Anhui 243000, China
Introduction: Diabetes mellitus patients are susceptible to various infections, including lung infections due to the impaired immunity functions. This study aimed to explore the potential parameters and their clinical values in the antibacterial therapy of diabetes mellitus complicated with pulmonary infection.
Materials and methods: A total of 112 patients with diabetes complicated with pulmonary infection from January 2019 to January 2022 in our hospital were enrolled in this study. Patients received the treatment of one or more kinds of antibiotics, and divided into the effective group (n=86) and void group (n=26) according to the treatment efficacy. The peripheral blood samples of patients were collected two times (before or during the treatment period). The parameters including mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), C-reactive protein to albumin ratio (CRP/ALB) in the two groups were monitored. Spearman analysis was used to explore the correlation between MPV, NLR, CRP/ALB parameters and treatment efficacy, and the multivariate logistic regression was used to find the factors influencing treatment efficacy. The ineffective values were predicted using the receiver operating characteristic curve (ROC).
Results: Significant difference was found in the distribution of patients with COPD and lung cancer between the two groups (p<0.05). In the first measurement, MPV, NLR, CRP/ALB parameters showed no significant difference in the two groups. In the second measurement, the levels of MPV, NLR, CRP/ALB parameters in the effective group were significantly lower than the void group (p<0.05). According to Spearman's analysis, the levels of MPV, NLR, CRP/ALB parameters were negatively correlated with the treatment efficacy in the second measurement (p<0.05). Moreover, logistic regression analysis revealed that MPV, NLR, CRP/ALB parameters were risk factors for treatment efficacy (p<0.05). The AUC was largest in the MPV, NLR, CRP/ALB combination group in the second measurement, and these parameters were of clinical prediction values for the therapy effect.
Conclusions: The decreased levels of MPV, NLR, CRP/ALB are correlated with the effective therapy in the diabetes complicated with lung infection. These parameters may provide clues to evaluate the patient treatment response in the clinical practice.
Diabetes mellitus, COPD, MPV, NLR, CRP/ALB.