CLINICAL VALUE OF TP-TE INTERVAL AND TP-TE/QT IN PREDICTING ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION

Jianmin Wu¹, Yingying Ruan¹, Yuanyuan Qian¹, Jiafeng Lin², Huaxian Lan^{1, *}

¹Department of ECG, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, PR China - ²Department of Internal Medicine-Cardiovascular, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, PR China

Introduction: To explore the clinical value of Tp-Te interval and Tp-Te/QT in predicting adverse cardiovascular events in patients with heart failure with preserved ejection fraction. 

Materials and methods: 162 patients with heart failure with preserved ejection fraction diagnosed and treated in our hospital from May 2017 to May 2022 were included. They were divided into the occurrence group (59 cases) and non-occurrence group (103 cases), according to the occurrence of adverse cardiovascular events during hospitalization. Univariate and multivariate methods were adopted to evaluate independent risk factors of adverse cardiovascular events during hospitalization and a ROC curve was drawn to analyze the clinical efficacy of Tp-Te interval combined with Tp-Te/QT in predicting the risk of adverse cardiovascular events during hospitalization. 

Results: There were significant differences between the two groups in terms of NT-proBNP level, Tp-Te interval, Tp-Te/QT, interventricular septal thickness and left ventricular posterior wall thickness (LVPWT) (P<0.05). In the univariate analysis, statistically significant indicators were included in Logistic regression model. The multivariate analysis showed that long Tp-Te interval and high Tp-Te/QT were independent risk factors of adverse cardiovascular events during hospitalization (P<0.05). The ROC analysis showed that Tp-Te interval combined with Tp-Te/QT was superior to the two indicators alone in predicting the risk of adverse cardiovascular events during hospitalization (P<0.05). 

Conclusion: Both Tp-Te interval and Tp-Te/QT can be used to predict adverse cardiovascular events in patients with heart failure with preserved ejection fraction, and the clinical prediction efficacy of Tp-Te interval combined with Tp-Te/QT is better than the two indicators alone.