STUDY ON THE EFFECT OF ARTIFICIAL HIP JOINT REPLACEMENT ON BLOOD VESSEL CECs, EPCs AND SERUM OSTEOCALCIN OF PATIENTS WITH TRAUMATIC OSTEONECROSIS OF THE FEMORAL HEAD

Guangjun Li^1#, Wen Shen^2#, Xiangqian Fang³, Yongliang Gao¹, Guowei Mo¹, Liqin Yao¹, Shuyin Sheng¹, Weidong Xu^1*

¹Department of Orthopedic, Deqing People’s Hospital, Huzhou, PR China - ²Department of Radiology, Deqing People's Hospital, Huzhou, PR China - ³Department of Orthopaedics, Sir Run Run Shaw Hospital, Hangzhou, PR China

Objective: We studied the effects of artificial hip joint replacement on blood vessel circulating endothelial cells (CECs), endothelial progenitor cells (EPCs) and serum osteocalcin of patients with traumatic osteonecrosis of the femoral head.

Methods: We chose 100 patients who had been diagnosed with traumatic osteonecrosis of the femoral head and who had accepted artificial hip joint replacement from May 2018 to May 2019 in our hospital and we regarded them as the observation group, and we selected 100 patients who had accepted a fixing treatment with various screws and took them as the control group. We examined preoperative and postoperative blood vessel CECs, EPCs and serum osteocalcin levels of the patients in both groups and statistically analysed them. 

Results: Before the operation, the Harris and visual analogue scale (VAS) scores of both groups were identical; after the operation, the Harris scores of the patients in the observation group were higher than those of the control group, and the VAS scores were lower than those of the control group; the differences were statistically significant (P<0.05). Before the operation, the blood vessel CEC and EPC levels of both groups were identical; after the operation, the blood vessel CECs of the patients in the observation group were lower than those of the control group, the numbers of blood vessel EPCs were higher than those of the control group, and these differences were statistically significant (P<0.05). Before the operation, the serum osteocalcin levels of the patients in both groups were identical; after the operation, the serum osteocalcin levels of the patients in the observation group were higher than those of control group, and the difference was statistically significant (P<0.05). 

Conclusion: Artificial hip joint replacement can affect blood vessel CECs, EPCs and serum osteocalcin of the patients and accordingly can promote recovery of patients with traumatic osteonecrosis of the femoral head.