Hong Xiao*, Xingguo Fang, Hai Zhang


Department of Digestive System, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, 553000, Guizhou Province, China


Background and aim: In recent years, the incidence of chronic atrophic gastritis which causes serious harm to people’s health has been increasing year by year. The high prevalence of atrophic gastritis requires us to do more research to explore its pathogenesis and find ways to prevent this disease. Thanks to advancement in modern science and technology, more accurate data can be obtained by using a scanning electron microscope. This article aims to study the changes in gastric mucosa in rats with atrophic gastritis caused by hypertonic saline. 

Methods: The experiment was carried out by establishing an animal model of atrophic gastritis in rats. Then scanning electron microscope was used to make various observations and the gastric mucosa of atrophic gastritis was analyzed after obtaining comprehensive data. 

Results: The results of the study showed that the gastric mucosal glands of rats were significantly reduced in the hypertonic saline group 32 weeks after saline gavage, and the thickness of the gastric mucosa decreased to 180μm. Glandular epithelial atrophy occurred in 1/3 to 2/3 of the gland, and gastric mucosa atrophy was more obvious. Under the action of hypertonic saline, the final cAMP content was reduced to 13pmol/ml. The gastric mucosa appeared with irregularly shaped erosions and fibrous exudates. 

Conclusion: It can be seen that the scanning electron microscope observation of the gastric mucosa of rats with atrophic gastritis caused by hypertonic saline is of great significance.


Hypertonic Saline, atrophic gastritis, gastric mucosa, electron microscope observation.