MIR-221 PROMOTES THE INVASION OF CERVICAL CANCER CELLS BY TARGETING ARID1A AND WNT/Β-CATENIN SIGNALING PATHWAY

Li Zuo^{1, #}, Ting Li^{2, #}, Fuxiang Liu^{3, *} 

¹Department of Oncology, Minhang Branch, Fudan University Cancer Hospital, Shanghai, 200240, Shanghai, China - ²Department of Gynaecology and Obsterics, The Second Affiliated Hospital of Nanhua University, Hengyang, 421000, Hunan, China - ³Department of Gynecology and Obstetrics, The 922nd Hospital of the PLA Joint Logistic Support Force, Hengyang, 421002, Hunan, China

Objective: Due to the lack of effective early clinical diagnosis of tumor molecular markers, most cervical cancer patients have been diagnosed in the middle and late stage, resulting in poor curative effects and high mortality, which poses a great threat to the health of women. 

Methods: In this study, we found that mir-221-3p was highly expressed in cervical squamous cell carcinoma, and the expression level of mir.221-3p was related to tumor vascular density. However, the mechanism of mir-221-3p in the angiogenesis of cervical cancer is not clear. Accordingly, the research content of this paper is that miR-221 promotes the invasion mechanism of cervical cancer cells. 

Result: The results showed that the amount of β-Catenin which could be degraded by proteasome pathway in the control group was less than that in the over-expressed cells of aridia, and aridia could promote the degradation of β-Catenin by proteasome pathway. 

Conclusion: The inhibition of the expression of mirna-221 can inactivate Wnt/β-Catenin pathway.