INTRAVENOUS INFUSION OF SOMATOSTATIN COMBINED WITH EXTERNAL USE OF MIRABILITE IN THE CONSERVATIVE TREATMENT OF PATIENTS DIAGNOSED OF ACUTE PANCREATITIS

Qian Shen^*, Bin Chen, Chun-shan Dai, Xiong-Hua Wang, Jie Shen

Department of General Surgery, Ningbo Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Ningbo, Zhejiang, China

Background: Intravenous administration of somatostatin is a standard treatment for patients diagnosed with acute pancreatitis (AP) and the external application of mirabilite is popular in China to treat patients with AP. Studies on the therapeutic effectiveness of the combination of somatostatin and mirabilite are lacking.

Methods: Retrospectively, patients with AP administered somatostatin and mirabilite were included in group A, while patients administered somatostatin treatment without mirabilite were included in group B. Demographic characteristics, clinical characteristics, and variables prior to discharge were compared between the groups.

Results: There were 65 patients and 50 patients in groups A and Group B, respectively. The demographic and clinical characteristics on admission showed no significant differences between the two groups (P>0.05). After treatment, group A showed shorter abdominal pain relief time, shorter abdominal distention relief time, quicker recovery of bowel movement, lesser fasting time, shorter body temperature normalization time, and shorter hospital stay than group B (P<0.05).

Conclusion: The external use of mirabilite combined with the intravenous infusion of somatostatin is more effective in the treatment of AP than somatostatin monotherapy. The combined regimen accelerated the recovery of gastrointestinal function and shortened the treatment cycle.