INFLUENCE FACTORS OF ENTEROCOLITIS RISK IN INFANTS WITH HIRSCHSPRUNG’ S DISEASE AFTER SURGICAL RESECTION

Jinhui Lin¹, Jiang Wu^{2, *},  Zhibo Qu¹, Jianhua Zhong¹, Yingsong Liu¹, Da Ma1, Qinfang Xu¹, Yi Wang¹ 

¹Department  of  Pediatric Surgery, Dongguan Children’s Hospital Affiliated to Guangdong Medical University, Dongguan, 523325, Guangdong, P R China - ²Department of Pediatric Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, PR China

Introduction: To investigate the influence factors of enterocolitis (EC) risk in infants with Hirschsprung’s disease after surgical resection.

Materials and methods: 109 infants with Hirschsprung’s disease after surgical resection who underwent pediatric surgical resection from January 2015 to December 2021 were included retrospectively, including 30 cases of postoperative EC. The baseline clinical characteristics of EC and non-EC groups were compared, and independent risk factors for postoperative EC were evaluated using a Logistic Regression model.

Results: There was no significant difference between 2 groups in age and gender (P>0.05). There were statistically significant differences in the proportions of preoperative intestinal lavage time≤14d, preoperative malnutrition, preoperative EC, intestinal flora disorder, dietary intervention, postoperative anastomotic fistula or stenosis and intestinal obstruction between 2 groups (P<0.05). Logistic regression model multivariate analysis showed that preoperative malnutrition, preoperative EC, intestinal flora disorder, concurrent intestinal obstruction, preoperative intestinal lavage time ≤14d, and postoperative anastomotic fistula or stenosis were all independent risk factors for postoperative EC (P<0.05).

Conclusion: The occurrence of EC after surgical resection in infants with Hirschsprung’s disease is related to many factors. Children who have preoperative malnutrition, preoperative EC, intestinal flora disorder, concurrent intestinal obstruction, preoperative intestinal lavage time≤14d, and postoperative anastomotic fistula or stenosis are more likely to develop postoperative EC.