EFFECT OF Ω-3 POLYUNSATURATED FATTY ACIDS IN PATIENTS WITH SEVERE PANCREATITIS

Li Liu^{1, #}, Li Huang^{2, #}, Na Li¹, Huajie Wang1, Li Li^3,*

¹Department of Critical Care Medicine, Hainan General Hospital, Haikou, Hainan 570311, China - ²Department of Neurology, Hainan General Hospital, Haikou, Hainan 570311, China - ³Department of Pediatrics, Hainan General Hospital, Haikou, Hainan 570311, China

Introduction: To determine the application value of extracorporeal shock wave therapy (ESWT) in rehabilitation nursing of patients with diabeticIntroduction: To investigate the value of omega-3 polyunsaturated fatty acids in patients with severe pancreatitis.

Materials and methods: Method Sixty patients with acute pancreatitis and intestinal palsy treated in the intensive care unit of our hospital from January 2019 to June 2020 were selected as the study subjects, and were divided into a control group and an experimental group according to the randomized table method, with 30 cases in each group, the control group was given a certain dose of conventional parenteral nutritional support therapy, and the experimental group was treated with ω-3 polyunsaturated fatty acids based on the treatment of the control group. The two groups were compared in terms of changes in the levels of inflammatory response parameters, APACHE-II scores, CT classification scores, the incidence of adverse events, complications, and satisfaction rate in preoperative and postoperative blood samples. 

Results: The results showed that after treatment, compared with the control group, the APACHE II score was significantly lower and the Ranson score of CT was significantly higher in the experimental group; compared with day 1, the expression levels of IL-1β, CRP and TNF-α began to decrease on day 5 in the control group SAP patients, and the difference was statistically significant (P < 0.05); however, day 3 in the experimental group had begun to The expression levels of IL-1β, CRP and TNF-α in the treatment group were significantly lower than those in the control group at the same time; the proportion of CD4 T lymphocytes in the treatment group was significantly lower on days 1 and 3, and the difference was statistically significant (P < 0.05); on day 5, the proportion of CD4 cells in the control group was still lower than that in the control group. In the control group, the difference was statistically significant (P < 0.05); however, the proportion of CD4 cells in the treatment group had returned to the normal level, and the difference was not statistically significant (P > 0.05); the complication rate of 10.00% in the experimental group was significantly lower than that of 36.67% in the control group, and the patient satisfaction rate was significantly higher in the intervention group compared with the control group. 

Conclusion: The application of ω-3 fish oil fat milk to the treatment of SAP patients can significantly improve the immune function of patients, reduce complications, effectively accelerate the recovery process, promote the therapeutic effect and significantly enhance patient satisfaction.