COMPARISON OF ULTRASTRUCTURE OBSERVATION OF MYOCARDIUM AND SKELETAL MUSCLE IN MICE INFECTED WITH LOW-DOSE VIBRIO VULNIFICUS

Yufeng Lin¹, Daojie Yan^{2, *}, Fengwei Jin³, Qing Mi⁴

¹Department of Respiratory Medicine, Jinan People’s Hospital, Jinan 271100, PR China - ²Department of Infectious Diseases, Jinan People’s Hospital, Jinan 271100, PR China - ³Department of Radiotherapy, Jinan People’s Hospital, Jinan 271100, PR China - ⁴Department of Internal Medicine-Neurology, Jinan People’s Hospital, Jinan 271100, PR China

Objective: The purpose of this article is to observe the microstructure changes of the myocardium and skeletal muscle of experimental mice before and after infection by using an electron microscope.

Method: Through comparative analysis of experimental data, we can promote our understanding of the treatment mechanisms of Vibrio vulnificus, so as to better treat and prevent various diseases caused by Vibrio vulnificus in the future.

Results: The results of the study showed that after treatment with low-dose Vibrio vulnificus, the experimental group mice developed obvious lesions in the myocardium. After the experiment was carried out for 3 hours, the myocardial muscle fibre gap gradually increased, and the submuscular oedema was more obvious than before the treatment; 6 hours after the experiment, the mouse myofilament sequence began to appear disordered and loose, and the myocardial muscle fibre gap expanded faster, about 3 hours after the experiment 8% of the experiment; 12 hours after the experiment, the skeletal muscle of the mice was dissolved, the interstitial tissue changed, and some experimental mice died.

Conclusion: The results of this experiment have certain reference value for the evolution of Vibrio vulnificus virulence factors