CLINICAL CURATIVE EFFECT OF CYTOKINES COMBINED WITH DOSE-VOLUME HISTOGRAM PARAMETERS AND FEATURES IN PREDICTING RADIATION-INDUCED LUNG INJURY FOR NON-SMALL CELL LUNG CANCER

Li Chu^*, Xuepin Yao, Yingxin Duan

Department of Radiotherapy and Chemotherapy, The Second Affiliated Hospital of Xingtai Medical College, Xingtai, 054000, Hebei Province, China

Objective: This study aimed to investigate the clinical features of patients with non-small cell lung cancer (NSCLC), the levels of interleukin-1 (IL-1), interleukinn-6 (IL-6), and tumor necrosis factor-α (TNF-α) in plasma before and after radiotherapy.

Methods: The correlation between dose-volume histogram (DVH) parameters and radiation-induced lung injury (RILI) was also studied. The clinical data of 200 patients with locally advanced NSCLC who received three-dimensional conformal radiotherapy (3D-CRT) in the hospital were retrospectively studied. These patients were divided into an occurrence group and a non-occurrence group. Enzyme-linked immunosorbent assay (ELISA) was adopted for detecting IL-1, IL-6, and TNF-α in plasma before and during radiotherapy. V₅, V₁₀, V₁₅, V₂₀, and mean lung dose (MLD) parameters were obtained from DVH, then the correlations between cytokines and DVH parameters as well as RILI were analyzed.

Result: The incidence of RILI was 30.5%, and the incidence of RILI with abnormal lung function before radiotherapy was 49.1%, which was higher than 25.5% in patients with normal lung function. IL-6 level in patients with RILI before radiotherapy was higher than that in the non-occurrence group. The V₅, V₁₀, and MLD in patients with RILI were higher than those in the non-occurrence group.

Conclusion: Multivariate analysis showed that IL-6, V₅, and V₁₀ were independent risk factors for RILI before radiotherapy. The IL-6 level combined with V₅ and V₁₀ had a good predictive effect on RILI in patients with NSCLC before radiotherapy.