Li Chu*, Xuepin Yao, Yingxin Duan
Department of Radiotherapy and Chemotherapy, The Second Affiliated Hospital of Xingtai Medical College, Xingtai, 054000, Hebei Province, China
Objective: This study aimed to investigate the clinical features of patients with non-small cell lung cancer (NSCLC), the levels of interleukin-1 (IL-1), interleukinn-6 (IL-6), and tumor necrosis factor-α (TNF-α) in plasma before and after radiotherapy.
Methods: The correlation between dose-volume histogram (DVH) parameters and radiation-induced lung injury (RILI) was also studied. The clinical data of 200 patients with locally advanced NSCLC who received three-dimensional conformal radiotherapy (3D-CRT) in the hospital were retrospectively studied. These patients were divided into an occurrence group and a non-occurrence group. Enzyme-linked immunosorbent assay (ELISA) was adopted for detecting IL-1, IL-6, and TNF-α in plasma before and during radiotherapy. V5, V10, V15, V20, and mean lung dose (MLD) parameters were obtained from DVH, then the correlations between cytokines and DVH parameters as well as RILI were analyzed.
Result: The incidence of RILI was 30.5%, and the incidence of RILI with abnormal lung function before radiotherapy was 49.1%, which was higher than 25.5% in patients with normal lung function. IL-6 level in patients with RILI before radiotherapy was higher than that in the non-occurrence group. The V5, V10, and MLD in patients with RILI were higher than those in the non-occurrence group.
Conclusion: Multivariate analysis showed that IL-6, V5, and V10 were independent risk factors for RILI before radiotherapy. The IL-6 level combined with V5 and V10 had a good predictive effect on RILI in patients with NSCLC before radiotherapy.
Cytokines, Dose-Volume Histogram Parameters, Non-Small Cell Lung Cancer, Radiation-Induced Lung Injury, Predictive Value.