THE RISK FACTORS OF INFECTION OF THE LOWER REPRODUCTIVE TRACT AND STREPTOCOCCUS B AND ITS INFLUENCE ON PREGNANCY OUTCOME

Jinli Liang¹, Na Han^2*

¹Department of Obstetrical, Qingdao Chengyang People's Hospital, Qingdao, 266000, China - ²Department of Obstetrics, Qingdao Women and Children's Hospital, Qingdao, 266011, China

Objective: This study aimed to analyze the risk factors of reproductive tract infection and b-streptococcus infection and their influence on pregnancy outcome. 

Methods: 60 pregnant and lying-in women who received regular examination in our hospital from August 2020 to March 2021 were randomly selected as the research subjects. Vaginal and rectal secretions were collected for bacterial culture of group B streptococcus. Real time fluorescent quantitative PCR was used for detection. According to whether the culture of group B Streptococcus had positive results, they were divided into infection group (n=29) and non-infection group (n=31). The clinical data of all subjects were collected, and the changes of clinical data of the two groups were compared. The risk factors of lower genital tract infection and group B streptococcus infection were analyzed. Logistic regression analysis was used to analyze the independent risk factors of lower genital tract infection and group B streptococcus infection. The pregnant women were followed up to the end of pregnancy to observe the effect of lower genital tract infection and group B streptococcus infection on pregnancy outcome and perinatal outcome. 

Results: 60 cases of lower genital tract infection and group B streptococcal infection were mainly under 35 years old, high school and below, and the number of antenatal examinations was not less than 7 times. Most of the pregnant women had no history of abortion, vaginitis, anemia during pregnancy, gestational diabetes mellitus, gestational hypertension and other diseases. They were mainly primiparas, and had a history of pregnancy protection during pregnancy. Compared with the uninfected group, the proportion of pregnant women with age ≥35 years old, prenatal examination times ≤ 6 times, vaginitis and abortion history in the infected group was significantly higher (P<0.05). Age, times of prenatal examination, vaginitis and abortion history may be the risk factors of lower genital tract infection and group B streptococcus infection. Logistic regression analysis showed that age, number of prenatal examination, abortion history and vaginitis were the independent risk factors for lower genital tract infection and group B streptococcus infection (P<0.05). Compared with the uninfected group, the incidence of amniotic infection, premature rupture of membranes, chorioamnionitis, postpartum hemorrhage and premature birth in the infected group were significantly higher (P<0.05); The incidence of neonatal infection, pneumonia, sepsis, intrauterine distress, hyperbilirubinemia and asphyxia in the infection group were significantly higher than those in the control group (P<0.05). 

Conclusion: Age, the number of prenatal examination, abortion history, vaginitis may be the independent risk factors of lower genital tract infection and group B streptococcus infection in pregnant women, and lower genital tract infection and group B streptococcus infection will cause serious adverse outcomes in pregnant women and newborns.