THE APPLICATION VALUE OF SERUM 3-NT AND NLRP3 IN THE DIAGNOSIS OF COGNITIVE IMPAIRMENT IN PATIENTS WITH ISCHEMIC WHITE MATTER LESIONS

Jin Wei¹, Xuzhang Jiao², Xiaoyan Gao³, Weiwei Qian^{4, *}

¹Three departments of Neurology,People's Hospital of Changyi City, Shandong Province, China-261300 - ²Department of Neurosurgery, People's Hospital of Changyi City, Shandong Province, China-261300 - ³Department of science and education, People's Hospital of Changyi City, Shandong Province, China-261300 - ⁴Division of Pulmonary and Critical Care Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People1’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China

Introduction: At present, few studies reported serum 3-NT, NLRP3 and cognitive dysfunction in patients with ischemic white matter disease. The objective of this study was to investigate the application value of serum 3 -nitrotyrosine (3-NT) and NLRP3 in the diagnosis of cognitive dysfunction in patients with ischemic white matter disease.

Methods: A total of 164 patients with ischemic white matter disease were included. According to the score of MoCA, the patients were divided into Group A (103 patients with cognitive impairment) and Group B (61 patients without cognitive impairment). Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of serum 3-NT and NLRP3 in patients with cognitive dysfunction. 

Results: MoCA score in Group A was lower than that in Group B (P<0.001), levels of serum 3-NT and NLRP3 in Group A were higher than those in Group B (both P<0.001). The AUC value and sensitivity of serum NLRP3 in the diagnosis of cognitive dysfunction in patients with ischemic white matter lesion were higher than those in serum 3-NT.

Conclusion: abnormal increase of serum 3-NT and NLRP3 levels can promote the occurrence of cognitive dysfunction in patients with ischemic white matter lesion. The diagnostic value of serum NLRP3 in patients with ischemic white matter lesion is higher than that of serum 3-NT.