Min Yang, Yingjing Gui, Hongbo Qian


Cardiothoracic surgery, Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College, Wuhu City, Anhui Province, China-241000


Objective: To investigate the significance of serum B-Type natriuretic peptide (BNP), Cardiac troponin I (cTnI) and Galectin-3 (Gal-3) in rheumatic valvular heart disease (RVD)-induced chronic heart failure (CHF) patients.

Study design: Case-control study.

Place and duration of study: Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College,China, from January 2017 to August 2021.

Methodology: Eighty-one RVD-induced CHF patients were included in the case group, and 81 healthy subjects with normal liver and kidney function and no other infection and immune diseases were selected as normal control group. Serum markers BNP, cTnI and Gal-3 were compared. 

Results: Levels of serum BNP, cTnI and Gal-3 in case group before treatment were higher than those in the normal control group (all p < 0.001). Before treatment, the above-mentioned markers levels between patients with NYHA grade II and grade III cardiac function were significant differences (all p< 0.001), and the above-mentioned markers levels in case group after treatment were lower than those before treatment (all p< 0.001). 

Conclusion: Serum BNP, cTnI and Gal-3 increased with the aggravation of cardiac function in RVD-induced CHF patients. The indexes above can be used to classify the cardiac function and evaluate the therapeutic effect in these patients.  


Rheumatic valvular heart disease (RVD) , Chronic heart failure (CHF) ,Serum markers, Galectin-3 (Gal-3).